Document Detail


Association of a gliotoxic activity with active multiple sclerosis in US patients.
MedLine Citation:
PMID:  11990456     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We recently found that cerebrospinal fluid (CSF) from multiple sclerosis (MS) patients contains a gliotoxic activity which induces programmed cell death of astrocytes and oligodendrocytes and could be the main contributing factor to the massive glial cell death seen in MS active lesions. A previous clinical study aimed at evaluating the gliotoxicity of CSF from a cohort of MS patients from France indicated that MS patients with the active form of the disease do indeed present significant CSF gliotoxicity. To extend this observation, the effect of 141 CSFs from United States patients with different neurological diseases (including 71 MS) was tested on immortalized astrocytes. A cell death assay showed that a gliotoxic activity is significantly present in the CSF from MS patients with the active forms. Thus, this gliotoxic activity may represent a critical pathogenic factor in the neuropathology of active MS by playing a role both in demyelinisation and alteration of the blood-brain barrier.
Authors:
R Pierig; J Belliveau; R Amouri; A Ménard; F Rieger
Related Documents :
3702896 - Analysis of sister-chromatid exchanges (sces) in familial and sporadic multiple sclerosis.
14692886 - Investigation of cytokine (tumor necrosis factor-alpha, interleukin-6, interleukin-10) ...
7674346 - Immunomodulation in the treatment of multiple sclerosis and amyotrophic lateral scleros...
20374346 - The manifestations of vasculopathy in systemic sclerosis and its evidence-based therapy.
6975826 - Hla-dr4 in negro and mexican rheumatoid arthritis patients.
22278236 - Expression of herv-fc1, a human endogenous retrovirus, is increased in patients with ac...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cellular and molecular biology (Noisy-le-Grand, France)     Volume:  48     ISSN:  0145-5680     ISO Abbreviation:  Cell. Mol. Biol. (Noisy-le-grand)     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-05-06     Completed Date:  2002-11-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9216789     Medline TA:  Cell Mol Biol (Noisy-le-grand)     Country:  France    
Other Details:
Languages:  eng     Pagination:  199-203     Citation Subset:  IM    
Affiliation:
INSERM U 488, Equipe Neuromodulations et Neuropathologies, Hĵpital du Kremlin-Bicêtre, Le Kremlin-Bicêtre, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Astrocytes / drug effects
Biological Assay
Case-Control Studies
Cerebrospinal Fluid / physiology*
Humans
Mice
Multiple Sclerosis / cerebrospinal fluid*
Reference Values
Toxicity Tests
United States

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hyperthermia assists survival of astrocytes from oxidative-mediated necrotic cell death.
Next Document:  Induction of cell death in rat brain by a gliotoxic factor from cerebrospinal fluid in multiple scle...