| Association of genetic variants with myocardial infarction in Japanese individuals with different lipid profiles. | |
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MedLine Citation:
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PMID: 20198310 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dyslipidemia is an important risk factor for myocardial infarction (MI). We previously showed that gene polymorphisms associated with MI differed among individuals with different lipid profiles. We further examined whether genetic variants that confer susceptibility to MI might differ among individuals with low or high serum concentrations of triglycerides, high density lipoprotein (HDL)-cholesterol, or low density lipoprotein (LDL)-cholesterol. The study population comprised 5270 Japanese individuals, including 1188 subjects with MI and 4082 controls. The 150 polymorphisms examined in the present study were selected by genome-wide association studies of MI and ischemic stroke with the use of the Affymetrix GeneChip Human Mapping 500K Array Set. The initial Chi-square test revealed that the A->G polymorphism (rs12632110) of SEMA3F was significantly (false discovery rate <0.05) associated with MI among individuals with high serum HDL-cholesterol or among those with low serum LDL-cholesterol. Subsequent multivariable logistic regression analysis with adjustment for covariates revealed that rs12632110 was significantly (P<0.01) associated with MI in individuals with high serum HDL-cholesterol or with low serum LDL-cholesterol. The genetic variants that confer susceptibility to MI differ among individuals with different lipid profiles, and the genetic component for the development of MI is more apparent in individuals at low-risk (high HDL- and low LDL-cholesterol levels) compared to those at high-risk. Stratification of subjects according to lipid profiles may thus be important for personalized prevention of MI based on genetic information. |
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Authors:
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Tetsuro Yoshida; Kimihiko Kato; Kiyoshi Yokoi; Mitsutoshi Oguri; Sachiro Watanabe; Norifumi Metoki; Hidemi Yoshida; Kei Satoh; Yukitoshi Aoyagi; Yoshinori Nozawa; Yoshiji Yamada |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of molecular medicine Volume: 25 ISSN: 1791-244X ISO Abbreviation: Int. J. Mol. Med. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-03 Completed Date: 2010-05-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9810955 Medline TA: Int J Mol Med Country: Greece |
Other Details:
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Languages: eng Pagination: 607-16 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Asian Continental Ancestry Group / genetics* Case-Control Studies Cholesterol, HDL / blood, genetics Cholesterol, LDL / blood, genetics Female Gene Frequency / genetics Genetic Predisposition to Disease* Humans Japan / ethnology Lipids / blood*, genetics* Logistic Models Male Myocardial Infarction / blood*, genetics* Polymorphism, Single Nucleotide / genetics* Triglycerides / blood, genetics |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipids; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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