| Association of genetic variants, ethnicity and preterm birth with amniotic fluid cytokine concentrations. | |
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MedLine Citation:
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PMID: 20369436 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the association of 166 single nucleotide polymorphisms (SNPs) in cytokines and cytokine related genes with cytokine concentrations (IL-1beta, IL-8, and IL-10) in the amniotic fluid (AF). These cytokines have been associated with spontaneous preterm birth (PTB) and their genetic regulation may play a role in disease risk. These associations were studied in both PTB and term births in African Americans and Caucasians; maternal and fetal genotypes were studied separately. Analyses modeled genotype, pregnancy status, and marker by pregnancy status (case/control) interaction with cytokine concentration as outcome. Our results indicate that AF cytokines (IL-1beta and IL-10) were associated with interactions between pregnancy status and both maternal and fetal SNPs, with the most significant interactions being observed for African Americans with IL-1beta concentration (maternal at IL1RAP rs1024941 p < 10(-3), fetal IL1RAP rs3773953 p < 10(-3)). AF IL-10 concentrations also showed evidence for association with SNPs in both ethnicities with the most significant interaction in Caucasian maternal samples (IL10 rs1800896 p < 10(-3)). Our data indicate that the genetic regulation of cytokine concentrations in PTB likely differs by ethnicity. AF cytokine concentrations were associated with interactions between genotype and PTB in African Americans, but less so in Caucasians. |
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Authors:
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Ramkumar Menon; Stephen J Fortunato; Digna R Velez Edwards; Scott M Williams |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of human genetics Volume: 74 ISSN: 1469-1809 ISO Abbreviation: Ann. Hum. Genet. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-04-06 Completed Date: 2010-05-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0416661 Medline TA: Ann Hum Genet Country: England |
Other Details:
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Languages: eng Pagination: 165-83 Citation Subset: IM |
Affiliation:
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The Perinatal Research Center, Nashville, TN, USA. rmenon3@emory.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult African Americans / genetics Amniotic Fluid / immunology* European Continental Ancestry Group / genetics Female Humans Interleukin-10 / analysis, genetics* Interleukin-1beta / analysis, genetics* Interleukin-8 / analysis, genetics Polymorphism, Single Nucleotide* Pregnancy Premature Birth / ethnology*, genetics* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1beta; 0/Interleukin-8; 130068-27-8/Interleukin-10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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