Document Detail

Association of a genetic variant of endothelial nitric oxide synthase with the 1 year clinical outcome after coronary stent placement.
MedLine Citation:
PMID:  12727149     Owner:  NLM     Status:  MEDLINE    
AIMS: Endothelial nitric oxide synthase (eNOS) catalyzes the formation of nitric oxide which has vasodilatory, antithrombotic, antiinflammatory and antiproliferative properties. The TT genotype of the single nucleotide polymorphism 894 G/T, located in exon 7 of the eNOS gene, was found to be associated with coronary spasm, coronary artery disease (CAD) and myocardial infarction (MI). We investigated the possibility that the 894 TT genotype has an unfavorable impact on the angiographic and clinical outcome after the placement of stents in coronary arteries. METHODS AND RESULTS: Our study included 1850 patients with CAD who were treated with stent implantation. Major adverse clinical events, including death, MI, and target vessel revascularization, were recorded for 1 year after the intervention. Patients with genotype 894 TT had an increase in the risk of death or MI (hazard ratio 2.14, 95% confidence interval (CI) 1.23-3.72; p=0.007), if compared with G allele carriers. TT patients showed no significant increase in the risk for angiographic restenosis (odds ratio (OR) 1.11, 95% CI 0.78-1.56; p=0.56) and target vessel revascularization (OR 1.21, 95% CI 0.82-1.78; p=0.34). CONCLUSIONS: In comparison with eNOS 894 G allele carriers, patients of the TT genotype were at an increased risk of death or MI within 1 year after coronary artery stenting.
Olga Gorchakova; Werner Koch; Nicolas von Beckerath; Julinda Mehilli; Albert Schömig; Adnan Kastrati
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  24     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-02     Completed Date:  2003-06-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  820-7     Citation Subset:  IM    
Deutsches Herzzentrum München, Technische Universität München, Lazarettstrasse 36, 80636 München, Germany.
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MeSH Terms
Acute Disease
Coronary Angiography
Coronary Artery Disease / enzymology*,  therapy
Coronary Stenosis / etiology
Coronary Thrombosis / etiology
Coronary Vasospasm / enzymology*
Middle Aged
Myocardial Infarction / enzymology*
Nitric Oxide Synthase / genetics*
Nitric Oxide Synthase Type III
Risk Factors
Reg. No./Substance:
EC protein, human; EC Oxide Synthase; EC Oxide Synthase Type III
Comment In:
Eur Heart J. 2004 Feb;25(3):277-8; author reply 278   [PMID:  14972431 ]

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