Document Detail


Association of a genetic variant of BTN2A1 with chronic kidney disease in Japanese individuals.
MedLine Citation:
PMID:  21557786     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim:  Although recent genetic studies suggested that several genetic variants increase the risk for chronic kidney disease (CKD), the genes that underlie genetic susceptibility to this condition remain to be identified definitively. We showed that the C → T polymorphism (rs6929846) of BTN2A1 and A → G polymorphism (rs2569512) of ILF3 were significantly associated with myocardial infarction in Japanese individuals by a genome-wide association study. The purpose of the present study was to examine a possible association of these polymorphisms (rs6929846, rs2569512) with CKD in Japanese individuals. Methods:  A total of 7542 Japanese individuals from two independent populations were examined: Subject panel A comprised 971 individuals with CKD [estimated glomerular filtration rate (eGFR) < 60 mL min(-1) 1.73m(-2) ] and 2269 controls (eGFR ≥ 60 mL min(-1) 1.73m(-2) ); and subject panel B comprised 1318 individuals with CKD and 2984 controls. Results:  The chi-square test revealed that rs6929846 of BTN2A1, but not rs2569512 of ILF3, was significantly related to the prevalence of CKD both in subject panels A (P= 0.0383) and B (P= 0.0477). Multivariable logistic regression analysis with adjustment for covariates revealed that the C → T polymorphism (rs6929846) of BTN2A1 was significantly associated with the prevalence of CKD in subject panels A (P= 0.0422; recessive model; odds ratio, 2.36) and B (P= 0.0386; dominant model; odds ratio, 1.21) with the T allele representing a risk for this condition. Conclusion:  Our results suggest that BTN2A1 may be a susceptibility gene for CKD in Japanese individuals.
Authors:
Tetsuro Yoshida; Kimihiko Kato; Hideki Horibe; Mitsutoshi Oguri; Michio Fukuda; Kei Satoh; Yukitoshi Aoyagi; Shoji Shinkai; Yoshinori Nozawa; Yoshiji Yamada
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-9
Journal Detail:
Title:  Nephrology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1797     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9615568     Medline TA:  Nephrology (Carlton)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. Nephrology © 2011 Asian Pacific Society of Nephrology.
Affiliation:
Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan; Meitoh Hospital, Nagoya and Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu; Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi; Department of Cardiology, Japanese Red Cross Nagoya First Hospital, Nagoya; Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya; Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki; Department of Genomics for Longevity and Health and Research Team for Social Participation and Health Promotion, Tokyo Metropolitan Institute of Gerontology, Tokyo; Gifu International Institute of Biotechnology and Tokai Gakuin University, Kakamigahara, Japan.
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