Document Detail


Association of genetic polymorphisms of vascular endothelial growth factor and risk for proliferative retinopathy of prematurity.
MedLine Citation:
PMID:  15635051     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The intention of our retrospective study was to determine whether vascular endothelial growth factor (VEGF) genetic polymorphisms are associated with risk for proliferative retinopathy of prematurity (ROP), a condition that is characterized by abnormal retinal neovascularization and can lead to retinal detachment and result in blindness. We enrolled 86 very low birth weight infants (birth weight < or =1500 g) who had been treated with cryo/laser therapy because of the risk for proliferative ROP (treated group). Their VEGF T-460C and G+405C genotypes were determined from dried blood samples and were compared with VEGF genotypes of 115 VLBW infants who were not treated with cryo/laser therapy (untreated group). We found that the allele frequency of VEGF +405C was higher in the treated group than in the untreated group (0.30 versus 0.41; p <0.05). The likelihood of being treated for ROP was higher in heterozygous and homozygous carriers of VEGF +405C alleles [odds ratios adjusted for risk factors of ROP (95% CI): 2.00 (1.02-3.92; p=0.04) and 3.37 (1.17-9.65; p=0.007), respectively]. VEGF -460TT/+405CC haplotype was more prevalent in the treated patients than in the untreated patients (13 of 86 versus 1 of 115; p <0.001), and the association remained significant (p <0.01) even after the adjustment for risk factors of ROP (gestational age, supplemental oxygen therapy, and gender). These findings suggest that the VEGF genotype may be associated with risk for proliferative ROP in VLBW infants.
Authors:
Adám Vannay; György Dunai; Ilona Bányász; Miklós Szabó; Rita Vámos; András Treszl; Júlia Hajdú; Tivadar Tulassay; Barna Vásárhelyi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-01-05
Journal Detail:
Title:  Pediatric research     Volume:  57     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-24     Completed Date:  2005-09-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  396-8     Citation Subset:  IM    
Affiliation:
Research Group for Paediatrics and Nephrology, Hungarian Academy of Sciences, Budapest, Hungary. vannay@gyer1.sote.hu
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MeSH Terms
Descriptor/Qualifier:
Female
Genotype
Humans
Infant
Infant, Newborn
Infant, Very Low Birth Weight
Male
Polymorphism, Genetic*
Retinopathy of Prematurity / genetics*,  metabolism
Retrospective Studies
Risk Factors
Vascular Endothelial Growth Factor A / genetics*
Chemical
Reg. No./Substance:
0/Vascular Endothelial Growth Factor A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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