| Association of gastric cancer with tyrosine hydroxylase gene polymorphism in a northwestern Chinese population. | |
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MedLine Citation:
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PMID: 17972051 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastric cancer (GC) is a common and complex disease caused by multifactors. The aim of our study was to investigate the association of the common polymorphisms detected in insulin-like growth factor (IGF)-II, IGF-1 receptor, insulin-like growth factor binding protein 1 (IGFBP1), insulin (INS) and tyrosine hydroxylase (TH) with susceptibility to GC in a northwestern Chinese population. One hundred and fifty-four GC patients and 166 healthy controls were investigated in our study. The genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism. The frequencies of CC and CT genotypes of TH were significantly higher in GC patients than in controls, as the odds ratios were 3.03 (95%CI 1.438-6.362, P=0.003) and 1.97 (95%CI 1.218-3.167, P=0.005), respectively. No association was found between the polymorphisms of IGF-II ApaI, insulin-like growth factor-1 receptor MnlI, IGFBP1 Bgl II and INS-23HphI and the development of GC. The presence of CC and CT genotypes of TH was associated with a significantly increased risk of GC. But the polymorphisms of other genes detected did not indicate an increased risk of GC in the investigated population. |
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Authors:
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Z Q Li; W P Yu; X D Xie; P Q Li; T K Guo; W H Zhang; L Z An; X L Wang |
Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2007-10-03 |
Journal Detail:
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Title: Clinical and experimental medicine Volume: 7 ISSN: 1591-8890 ISO Abbreviation: Clin. Exp. Med. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-10-31 Completed Date: 2007-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100973405 Medline TA: Clin Exp Med Country: Italy |
Other Details:
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Languages: eng Pagination: 98-101 Citation Subset: IM |
Affiliation:
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School of Life Science, Lanzhou University, Lanzhou City, Gansu Province, China 730000. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Asian Continental Ancestry Group
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genetics* Case-Control Studies China / epidemiology Dinucleotide Repeats / genetics* Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Insulin / genetics Insulin-Like Growth Factor Binding Protein 1 / genetics Insulin-Like Growth Factor II / genetics Male Polymorphism, Genetic / genetics* Receptors, Somatomedin / genetics Stomach Neoplasms / enzymology, epidemiology, genetics* Tyrosine 3-Monooxygenase / genetics* |
| Chemical | |
Reg. No./Substance:
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0/IGFBP1 protein, human; 0/Insulin-Like Growth Factor Binding Protein 1; 0/Receptors, Somatomedin; 11061-68-0/Insulin; 67763-97-7/Insulin-Like Growth Factor II; EC 1.14.16.2/Tyrosine 3-Monooxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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