Document Detail


Association of functional polymorphisms related to the transcriptional level of FOXP3 with prognosis of autoimmune thyroid diseases.
MedLine Citation:
PMID:  20942809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The severity of Hashimoto's disease (HD) and intractability (or inducibility to remission) of Graves' disease (GD) varies among patients. Forkhead box P3 (FoxP3) is a crucial regulatory factor for the development and function of regulatory T (T(reg) ) cells, and deficiency of the FoxP3 gene (FOXP3) suppresses the regulatory function of T(reg) cells. To clarify the association of the functional polymorphisms of the FOXP3 with the prognosis of GD and HD, we genotyped -3499A/G, -3279C/A and -2383C/T polymorphisms in FOXP3 gene obtained from 38 patients with severe HD, 40 patients with mild HD, 65 patients with intractable GD, in whom remission was difficult to induce, 44 patients with GD in remission and 71 healthy volunteers. The -3279CA genotype was more frequent in patients with GD in remission than in patients with intractable GD, and the -3279AA genotype, which correlates to defective transcription of FOXP3, was absent in patients with GD in remission. The -2383CC genotype was more frequent in patients with severe HD than in those with mild HD. In conclusion, the -3279A/C polymorphism is related to the development and intractability of GD and the -2383CC genotype to the severity of HD.
Authors:
N Inoue; M Watanabe; M Morita; R Tomizawa; T Akamizu; K Tatsumi; Y Hidaka; Y Iwatani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-05
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  162     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-12     Completed Date:  2011-03-08     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  402-6     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Clinical and Experimental Immunology © 2010 British Society for Immunology.
Affiliation:
Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine, Yamadaoka 1-7 Suita, Osaka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Child
Disease Progression
Female
Forkhead Transcription Factors / genetics*
Genetic Association Studies
Graves Disease / diagnosis*,  drug therapy,  genetics*,  physiopathology
Hashimoto Disease / diagnosis*,  drug therapy,  genetics*,  physiopathology
Humans
Hypothyroidism
Japan
Male
Middle Aged
Polymorphism, Single Nucleotide
Prognosis
Promoter Regions, Genetic
Remission Induction
Chemical
Reg. No./Substance:
0/FOXP3 protein, human; 0/Forkhead Transcription Factors
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