| Association of functional haem oxygenase-1 gene promoter polymorphism with polycystic kidney disease and IgA nephropathy. | |
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MedLine Citation:
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PMID: 18045827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Haem oxygenase-1 (HO-1) is a cytoprotective molecule that is reported to have a protective role in a variety of experimental models of renal injury. A functional dinucleotide repeat (GT)(n) polymorphism, within the HO-1 promoter, regulates HO-1 gene expression; a short number of repeats (S-allele <25) increases transcription. We report the first assessment of the role of this HO-1 gene promoter polymorphism in chronic kidney disease due to autosomal dominant polycystic kidney disease (ADPKD) and IgA nephropathy (IgAN). METHODS: The DNA from 160 patients (99% Caucasian) on renal replacement therapy (RRT) was genotyped. The primary renal disease was ADPKD in 100 patients and biopsy-proven IgAN in 60 patients. RESULTS: Overall, the mean age at commencement of RRT was not significantly different between patients with and without an S-allele (44.1 years versus 45.0 years, P = 0.64). In patients with ADPKD, the age at commencement of RRT was comparable regardless of the HO-1 genotype (47.7 years versus 46.7 years, P = 0.59). The same was true in patients with IgAN (38.3 years versus 42.2 years, P = 0.28). CONCLUSION: This suggests that the functional HO-1 promoter polymorphism does not influence renal survival in CKD due to ADPKD or IgAN. |
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Authors:
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Aisling E Courtney; Peter T McNamee; Shirley Heggarty; Derek Middleton; A Peter Maxwell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-11-28 |
Journal Detail:
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Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 23 ISSN: 1460-2385 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-07 Completed Date: 2008-07-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: England |
Other Details:
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Languages: eng Pagination: 608-11 Citation Subset: IM |
Affiliation:
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Nephrology Research Group, Queen's University Belfast, Belfast, UK. aecourtney@doctors.org.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Glomerulonephritis, IGA / complications, genetics* Heme Oxygenase-1 / genetics* Humans Kidney Failure, Chronic / complications, genetics* Male Middle Aged Polycystic Kidney Diseases / complications, genetics* Polymorphism, Genetic* Promoter Regions, Genetic |
| Chemical | |
Reg. No./Substance:
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EC 1.14.99.3/Heme Oxygenase-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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