Document Detail


Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers.
MedLine Citation:
PMID:  17206495     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: Catechol-O-methyltransferase (COMT) is an enzyme involved in the degradation and inactivation of the neurotransmitter dopamine, which is important in mediating drug reward such as nicotine in tobacco smoke. Different COMT alleles encode enzyme whose activity varies from three- to fourfold that may affect dopamine levels and alter subjective effects of nicotine. Recent evidence also suggests that a COMT polymorphism may be especially important in determining an individual's predisposition to developing nicotine dependence. SUBJECTS AND METHODS: We studied the COMT Val108Met polymorphism in a male population of 203 current smokers, 66 former smokers, and 102 non-smokers. The age-adjusted odds ratios were estimated by multiple logistic regression models. RESULTS: The results showed no significant association of the COMT Val108Met with initiation, persistent smoking, or smoking cessation. However, current smokers with the Met allele had significantly higher Fagerstrom Test for Nicotine Dependence scores (7.5 +/- 2.1 vs 6.8 +/- 1.8, p = 0.018) and started smoking significantly earlier (18.4 +/- 4.9 vs 20.1 +/- 5.9 years, p = 0.036). CONCLUSIONS: These results suggest that the COMT Val108Met polymorphism may not influence smoking status in a Chinese male population but may influence the age at which smoking started and smoking severity among smokers. However, the findings must be regarded as preliminary because of the relatively small sample size and marginal associations and should be replicated in a larger cohort.
Authors:
Song Guo; Da Fang Chen; Dong Feng Zhou; Hong Qiang Sun; Gui Ying Wu; Colin N Haile; Therese A Kosten; Thomas R Kosten; Xiang Yang Zhang
Related Documents :
6591365 - Secretion rate, buffer effect and number of lactobacilli and streptococcus mutans of wh...
11711245 - Growth and pubertal milestones during adolescence in offspring prenatally exposed to ci...
8536415 - The effects of cigarette smoking and alcohol consumption on blood haemoglobin, erythroc...
4062035 - Patterns of spirogram abnormality in individual smokers.
1734525 - Aromatase enzyme activity and sex determination in chickens.
18827655 - Evaluation of age-related intraorbital fat herniation through computed tomography.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-01-06
Journal Detail:
Title:  Psychopharmacology     Volume:  190     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-01     Completed Date:  2007-04-06     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  449-56     Citation Subset:  IM    
Affiliation:
Institute of Mental Health, Peking University, Beijing, 100083, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Asian Continental Ancestry Group / genetics*
Catechol O-Methyltransferase / genetics*
China
Cohort Studies
Genetic Predisposition to Disease
Genotype
Humans
Logistic Models
Male
Methionine
Middle Aged
Odds Ratio
Polymorphism, Genetic*
Smoking / genetics*,  metabolism
Smoking Cessation
Tobacco Use Disorder / enzymology,  genetics*
Valine
Grant Support
ID/Acronym/Agency:
K05-DA0454/DA/NIDA NIH HHS; P50-DA18827/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
63-68-3/Methionine; 7004-03-7/Valine; EC 2.1.1.6/Catechol O-Methyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  An investigation of the behavioral actions of ethanol across adolescence in mice.
Next Document:  The dynamic vacuum orthosis: a functional and economical benefit?