Document Detail

Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers.
MedLine Citation:
PMID:  17206495     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Catechol-O-methyltransferase (COMT) is an enzyme involved in the degradation and inactivation of the neurotransmitter dopamine, which is important in mediating drug reward such as nicotine in tobacco smoke. Different COMT alleles encode enzyme whose activity varies from three- to fourfold that may affect dopamine levels and alter subjective effects of nicotine. Recent evidence also suggests that a COMT polymorphism may be especially important in determining an individual's predisposition to developing nicotine dependence. SUBJECTS AND METHODS: We studied the COMT Val108Met polymorphism in a male population of 203 current smokers, 66 former smokers, and 102 non-smokers. The age-adjusted odds ratios were estimated by multiple logistic regression models. RESULTS: The results showed no significant association of the COMT Val108Met with initiation, persistent smoking, or smoking cessation. However, current smokers with the Met allele had significantly higher Fagerstrom Test for Nicotine Dependence scores (7.5 +/- 2.1 vs 6.8 +/- 1.8, p = 0.018) and started smoking significantly earlier (18.4 +/- 4.9 vs 20.1 +/- 5.9 years, p = 0.036). CONCLUSIONS: These results suggest that the COMT Val108Met polymorphism may not influence smoking status in a Chinese male population but may influence the age at which smoking started and smoking severity among smokers. However, the findings must be regarded as preliminary because of the relatively small sample size and marginal associations and should be replicated in a larger cohort.
Song Guo; Da Fang Chen; Dong Feng Zhou; Hong Qiang Sun; Gui Ying Wu; Colin N Haile; Therese A Kosten; Thomas R Kosten; Xiang Yang Zhang
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-01-06
Journal Detail:
Title:  Psychopharmacology     Volume:  190     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-01     Completed Date:  2007-04-06     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  449-56     Citation Subset:  IM    
Institute of Mental Health, Peking University, Beijing, 100083, China.
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MeSH Terms
Age Factors
Asian Continental Ancestry Group / genetics*
Catechol O-Methyltransferase / genetics*
Cohort Studies
Genetic Predisposition to Disease
Logistic Models
Middle Aged
Odds Ratio
Polymorphism, Genetic*
Smoking / genetics*,  metabolism
Smoking Cessation
Tobacco Use Disorder / enzymology,  genetics*
Grant Support
Reg. No./Substance:
63-68-3/Methionine; 7004-03-7/Valine; EC O-Methyltransferase

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