Document Detail


Association frequency and silver staining of nucleolus organizing regions in hyperthyroid patients.
MedLine Citation:
PMID:  6156113     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The intensity of the silver staining of nucleolus organizing regions (NORs) and the frequency of chromosomal associations were studied before and after antithyroid treatment in seven and eight hyperthyroid patients, respectively. For one patient, the NOR staining was significantly more intense after treatment, while for another the opposite result was found. A higher stainability of chromosome 22 was observed after treatment in six of seven patients. The difference was significant for the group of patients considered as a whole but only for one patient considered separately. Chromosome 22 also showed an increased association frequency. Fro one patient, the number of large associations and the total number of associating chromosomes was also significantly increased after treatment. A decrease of associating chromosomes 14 and 21 such as was reported by Nilsson et al, (1975) after antithyroid treatment could not be found in our sample. The possible reason for this difference are discussed.
Authors:
H Zankl; C Mayer; K D Zang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human genetics     Volume:  54     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1980  
Date Detail:
Created Date:  1980-09-23     Completed Date:  1980-09-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  111-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Chromosomes, Human / ultrastructure
Humans
Hyperthyroidism / genetics*
Karyotyping
Lymphocytes / ultrastructure
Nucleolus Organizer Region / ultrastructure*
Silver
Staining and Labeling
Chemical
Reg. No./Substance:
7440-22-4/Silver

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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