Document Detail


Association of fetal inflammation and coagulation pathway gene polymorphisms with neurodevelopmental delay at age 2 years.
MedLine Citation:
PMID:  20417488     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to evaluate the association between fetal inflammation and coagulation gene single-nucleotide polymorphisms (SNPs) and neurodevelopmental delay at age 2 years.
STUDY DESIGN: We conducted a case-controlled secondary analysis of a randomized trial of single- vs multiple-course corticosteroids. Multiplex assay assessed 46 SNPs. Cases had mental developmental and/or psychomotor delay at age 2 years. Control subjects had normal neurodevelopment.
RESULTS: One hundred twenty-five cases and 147 control subjects were analyzed. Allele frequencies were different between cases and control subjects for interleukin (IL)1beta-511 (P = .009), IL4R-148 (P = .03), IL6-174 (P = .02), and IL6-176 (P = .007). Genotype frequencies were different for IL1beta-511 (P = .03) and IL6-174 (P = .04). Results for IL1beta-511, IL4R-148, and IL6-176 remained significant after logistic regression analysis. IL1beta-511 and IL6-176 minor alleles were associated with increased risk of neurodevelopmental delay (odds ratio, 3.1; 95% confidence interval [CI], 1.2-8.2 and 2.2; 95% CI, 1.2-3.9, respectively). IL4R-148 minor allele was protective (odds ratio, 0.6; 95% CI, 0.4-0.9).
CONCLUSION: Fetal SNPs in IL1beta, IL-4R, and IL-6 may be associated with neurodevelopmental delay at age 2 years.
Authors:
Erin A S Clark; Lisa Mele; Ronald J Wapner; Catherine Y Spong; Yoram Sorokin; Alan Peaceman; Jay D Iams; Kenneth J Leveno; Margaret Harper; Steve N Caritis; Menachem Miodovnik; Brian M Mercer; John M Thorp; Susan M Ramin; Marshall Carpenter; Dwight J Rouse;
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2010-04-24
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  203     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-09-03     Revised Date:  2014-05-08    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  83.e1-83.e10     Citation Subset:  AIM; IM    
Copyright Information:
Copyright (c) 2010 Mosby, Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Blood Coagulation Disorders / blood,  genetics*
Case-Control Studies
Child, Preschool
DNA / chemistry,  genetics
Female
Genetic Variation
Genotype
Humans
Inflammation / blood,  genetics*
Interleukins / biosynthesis,  genetics
Logistic Models
Male
Nervous System Diseases / blood,  genetics*
Placenta / pathology
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Pregnancy
Grant Support
ID/Acronym/Agency:
HD21410/HD/NICHD NIH HHS; HD27860/HD/NICHD NIH HHS; HD27869/HD/NICHD NIH HHS; HD27915/HD/NICHD NIH HHS; HD27917/HD/NICHD NIH HHS; HD34116/HD/NICHD NIH HHS; HD34136/HD/NICHD NIH HHS; HD34208/HD/NICHD NIH HHS; HD36801/HD/NICHD NIH HHS; HD40485/HD/NICHD NIH HHS; HD40500/HD/NICHD NIH HHS; HD40512/HD/NICHD NIH HHS; HD40544/HD/NICHD NIH HHS; HD40545/HD/NICHD NIH HHS; HD40560/HD/NICHD NIH HHS; M01-RR-000080/RR/NCRR NIH HHS; R24 HD050924-07/HD/NICHD NIH HHS; U10 HD021410/HD/NICHD NIH HHS; U10 HD021410-22/HD/NICHD NIH HHS; U10 HD027860-15/HD/NICHD NIH HHS; U10 HD027869-18/HD/NICHD NIH HHS; U10 HD027915-18/HD/NICHD NIH HHS; U10 HD027917-18/HD/NICHD NIH HHS; U10 HD034116-13/HD/NICHD NIH HHS; U10 HD034136-10/HD/NICHD NIH HHS; U10 HD034208-12/HD/NICHD NIH HHS; U10 HD036801/HD/NICHD NIH HHS; U10 HD036801-11/HD/NICHD NIH HHS; U10 HD040485-09/HD/NICHD NIH HHS; U10 HD040500-09/HD/NICHD NIH HHS; U10 HD040512-10/HD/NICHD NIH HHS; U10 HD040544-09/HD/NICHD NIH HHS; U10 HD040545-09/HD/NICHD NIH HHS; U10 HD040560-09/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Interleukins; 9007-49-2/DNA
Comments/Corrections

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