| Association of fatty acids in serum phospholipids with lung function and bronchial hyperresponsiveness in adults. | |
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MedLine Citation:
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PMID: 18204906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The dietary intake of certain fatty acids might have an impact on inflammatory processes in the lung and therefore contribute to the development of lung diseases like asthma or COPD. METHODS: In this study data from a population based cross-sectional study on respiratory health including measurement of fatty acids in serum phospholipids of 593 adults between 20 and 64 years of age were analyzed. RESULTS: Statistically significant positive associations were found between percentage predicted FEV1 (P = 0.0085) and FVC (P = 0.0267) and docosahexaenoic acid concentration in serum phospholipids in men. Dihomo-gamma-linolenic acid content in serum phospholipids was significantly negatively associated with percentage predicted FEV1 (P = 0.0003) and FVC (P = 0.0045) and transformed dose-response slopes (P = 0.0488) in men. Palmitoleic acid was negatively associated with percentage predicted FEV1 (P = 0.0037) and FVC (P = 0.0029) in men. Other fatty acids in serum phospholipids did not consistently affect lung function parameters or bronchial hyperreactivity. CONCLUSION: A high concentration of docosahexaenoic acid in serum phospholipids may have a protective effect on lung function. Because this long-chain n-3 polyunsaturated fatty acid is almost exclusively derived from marine oils, fish might have a beneficial effect on lung diseases. |
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Authors:
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Iris Kompauer; Hans Demmelmair; Berthold Koletzko; Gabriele Bolte; Jakob Linseisen; Joachim Heinrich |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-01-16 |
Journal Detail:
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Title: European journal of epidemiology Volume: 23 ISSN: 0393-2990 ISO Abbreviation: Eur. J. Epidemiol. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-02-19 Completed Date: 2008-11-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508062 Medline TA: Eur J Epidemiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 175-90 Citation Subset: IM |
Affiliation:
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Institute of Epidemiology, GSF - National Research Center for Environment and Health, P.O. Box 1129, 85758, Neuherberg, Germany. iriskompauer@rps.bwl.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bronchial Hyperreactivity / blood*, physiopathology* Fatty Acids / blood* Female Humans Lung / physiopathology* Male Middle Aged Odds Ratio Phospholipids / blood*, chemistry Respiratory Function Tests Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Phospholipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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