| Association of the fatty acid composition of serum phospholipids with hemostatic factors. | |
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MedLine Citation:
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PMID: 9157941 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been suggested that the fatty acid composition of serum phospholipids is an independent risk factor for cardiovascular disease. We examined the association of the fatty acid composition of serum phospholipids with fibrinogen, factor VII antigen (FVII:Ag), factor VII coagulant activity (FVII:C), plasminogen, and lipoprotein(a) [Lp(a)] in 338 men and 363 women 45 to 64 years old. Palmitic acid, the most abundant saturated fatty acid, was positively associated in univariate analyses with plasminogen, which explained 5.2% of its variance among men (P<.0001) and 5.8% among women (P<.0001). Linoleic acid, which is the most abundant polyunsaturated fatty acid, was negatively associated with plasminogen and fibrinogen. This explained 1.1% of the variance in fibrinogen among men (P=.04) and 3.2% among women (P=.0006) and 4.1% of the variance in plasminogen in both sexes (P<.0001). Dihomogammalinolenic acid was positively associated with FVII:Ag and explained 3.7% of its variance among men (P=.0003) and 4.6% among women (P<.0001). Furthermore, dihomogammalinolenic acid was positively and significantly associated with FVII:C, fibrinogen, and plasminogen among women but not among men. All these associations remained significant after adjustment for multiple potential confounding factors such as age, smoking, serum lipids, and body mass index. In conclusion, our findings suggest that linoleic acid, palmitic acid, and dihomogammalinoleic acid are significant independent determinants of hemostatic profile. It is not clear, however, to what extent these results reflect the effects of fatty acids on coagulation and to what extent they reflect the activity of inflammatory processes in the arteries. |
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Authors:
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V V Salomaa; I Salminen; V Rasi; E Vahtera; A Aro; G Myllylä |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 17 ISSN: 1079-5642 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-06-12 Completed Date: 1997-06-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 809-13 Citation Subset: IM |
Affiliation:
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Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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8,11,14-Eicosatrienoic Acid
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blood Antigens / metabolism Coronary Disease / blood Factor VII / metabolism Fatty Acids / blood* Female Fibrinogen / metabolism Hemostasis* Humans Linoleic Acid Linoleic Acids / blood Lipoprotein(a) / blood Male Middle Aged Palmitic Acid / blood Phospholipids / blood* Plasminogen / metabolism Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Fatty Acids; 0/Linoleic Acids; 0/Lipoprotein(a); 0/Phospholipids; 0/factor VII clotting antigen; 2197-37-7/Linoleic Acid; 57-10-3/Palmitic Acid; 7324-41-6/8,11,14-Eicosatrienoic Acid; 9001-25-6/Factor VII; 9001-32-5/Fibrinogen; 9001-91-6/Plasminogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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