Document Detail


Association of p53/p21 expression with cigarette smoking and prognosis in esophageal squamous cell carcinoma patients.
MedLine Citation:
PMID:  20954283     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To investigate the expression of p53 and p21 and associations with possible risk factors, such as cigarette smoking, in esophageal squamous cell carcinoma (ESCC) in northeastern Iran, a region with a high incidence of ESCC.
METHODS: The expression of p53 and p21 proteins was investigated immunohistochemically in tumor tissue from 80 ESCC patients and in 60 available paraffin-embedded blocks of adjacent normal specimens from the cases, along with normal esophageal tissue from 80 healthy subjects.
RESULTS: Positive expression of p53 protein was detected in 56.2% (45/80) of ESCC cases, and in none of the normal esophageal tissue of the control group (P < 0.001). Furthermore, 73.8% (59/80) of ESCC cases and 43.8% (35/80) of controls had positive expression of p21 protein (P < 0.001). Cigarette smoking was significantly associated with p53 over-expression in ESCC cases (P = 0.010, OR = 3.64; 95% CI: 1.32-10.02). p21 over-expression was associated with poorer clinical outcome among the ESCC patients (P = 0.009).
CONCLUSION: Over-expression of p53 in association with cigarette smoking may play a critical role in ESCC carcinogenesis among this high-risk population of northeastern Iran. Furthermore, p21 over-expression was found to be associated with poor prognosis, specifically in the operable ESCC patients.
Authors:
Noushin Taghavi; Firouzeh Biramijamal; Masoud Sotoudeh; Omeed Moaven; Hooman Khademi; Mohammad Reza Abbaszadegan; Reza Malekzadeh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  16     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-18     Completed Date:  2011-02-01     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  4958-67     Citation Subset:  IM    
Affiliation:
Department of Medical Genetics, National Institute for Genetic Engineering and Biotechnology, Shahrak-e Pajoohesh, 17km, Tehran-Karaj High way, PO Box 14965/161, Tehran 14977-16316, Iran.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell / chemistry*,  epidemiology,  pathology
Case-Control Studies
Chi-Square Distribution
Cyclin-Dependent Kinase Inhibitor p21 / analysis*
Esophageal Neoplasms / chemistry*,  epidemiology,  pathology
Female
Humans
Immunohistochemistry
Incidence
Iran / epidemiology
Kaplan-Meier Estimate
Logistic Models
Male
Middle Aged
Odds Ratio
Prognosis
Proportional Hazards Models
Risk Assessment
Risk Factors
Smoking / epidemiology*
Tumor Markers, Biological / analysis*
Tumor Suppressor Protein p53 / analysis*
Chemical
Reg. No./Substance:
0/CDKN1A protein, human; 0/Cyclin-Dependent Kinase Inhibitor p21; 0/TP53 protein, human; 0/Tumor Markers, Biological; 0/Tumor Suppressor Protein p53
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