| Association of p53/p21 expression with cigarette smoking and prognosis in esophageal squamous cell carcinoma patients. | |
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MedLine Citation:
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PMID: 20954283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To investigate the expression of p53 and p21 and associations with possible risk factors, such as cigarette smoking, in esophageal squamous cell carcinoma (ESCC) in northeastern Iran, a region with a high incidence of ESCC. METHODS: The expression of p53 and p21 proteins was investigated immunohistochemically in tumor tissue from 80 ESCC patients and in 60 available paraffin-embedded blocks of adjacent normal specimens from the cases, along with normal esophageal tissue from 80 healthy subjects. RESULTS: Positive expression of p53 protein was detected in 56.2% (45/80) of ESCC cases, and in none of the normal esophageal tissue of the control group (P < 0.001). Furthermore, 73.8% (59/80) of ESCC cases and 43.8% (35/80) of controls had positive expression of p21 protein (P < 0.001). Cigarette smoking was significantly associated with p53 over-expression in ESCC cases (P = 0.010, OR = 3.64; 95% CI: 1.32-10.02). p21 over-expression was associated with poorer clinical outcome among the ESCC patients (P = 0.009). CONCLUSION: Over-expression of p53 in association with cigarette smoking may play a critical role in ESCC carcinogenesis among this high-risk population of northeastern Iran. Furthermore, p21 over-expression was found to be associated with poor prognosis, specifically in the operable ESCC patients. |
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Authors:
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Noushin Taghavi; Firouzeh Biramijamal; Masoud Sotoudeh; Omeed Moaven; Hooman Khademi; Mohammad Reza Abbaszadegan; Reza Malekzadeh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 16 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-18 Completed Date: 2011-02-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 4958-67 Citation Subset: IM |
Affiliation:
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Department of Medical Genetics, National Institute for Genetic Engineering and Biotechnology, Shahrak-e Pajoohesh, 17km, Tehran-Karaj High way, PO Box 14965/161, Tehran 14977-16316, Iran. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Carcinoma, Squamous Cell / chemistry*, epidemiology, pathology Case-Control Studies Chi-Square Distribution Cyclin-Dependent Kinase Inhibitor p21 / analysis* Esophageal Neoplasms / chemistry*, epidemiology, pathology Female Humans Immunohistochemistry Incidence Iran / epidemiology Kaplan-Meier Estimate Logistic Models Male Middle Aged Odds Ratio Prognosis Proportional Hazards Models Risk Assessment Risk Factors Smoking / epidemiology* Tumor Markers, Biological / analysis* Tumor Suppressor Protein p53 / analysis* |
| Chemical | |
Reg. No./Substance:
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0/CDKN1A protein, human; 0/Cyclin-Dependent Kinase Inhibitor p21; 0/TP53 protein, human; 0/Tumor Markers, Biological; 0/Tumor Suppressor Protein p53 |
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