| Association of exposure to diabetes in utero with adiposity and fat distribution in a multiethnic population of youth: the Exploring Perinatal Outcomes among Children (EPOCH) Study. | |
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MedLine Citation:
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PMID: 20953862 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS/HYPOTHESIS: To evaluate whether exposure to maternal gestational diabetes (GDM) is associated with adiposity and fat distribution in a multiethnic population of children. METHODS: Retrospective cohort study of 82 children exposed to maternal GDM and 379 unexposed youths 6-13 years of age with measured BMI, waist circumference, skinfold thickness, and visceral and subcutaneous abdominal fat. RESULTS: Exposure to maternal GDM was associated with higher BMI (p = 0.02), larger waist circumference (p = 0.004), more subcutaneous abdominal fat (p = 0.01) and increased subscapular to triceps skinfold thickness ratio (p = 0.01) in models adjusted for age, sex, race/ethnicity and Tanner stage. Adjustment for socioeconomic factors, birthweight and gestational age, maternal smoking during pregnancy and current diet and physical activity did not influence associations; however, adjustment for maternal pre-pregnancy BMI attenuated all associations. CONCLUSIONS/INTERPRETATION: Exposure to maternal GDM is associated with increased overall and abdominal adiposity, and a more central fat distribution pattern in 6- to 13-year-old youths from a multi-ethnic population, providing further support for the fetal overnutrition hypothesis. |
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Authors:
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T L Crume; L Ogden; N A West; K S Vehik; A Scherzinger; S Daniels; R McDuffie; K Bischoff; R F Hamman; J M Norris; D Dabelea |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-10-17 |
Journal Detail:
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Title: Diabetologia Volume: 54 ISSN: 1432-0428 ISO Abbreviation: Diabetologia Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-02 Completed Date: 2011-05-11 Revised Date: 2012-01-04 |
Medline Journal Info:
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Nlm Unique ID: 0006777 Medline TA: Diabetologia Country: Germany |
Other Details:
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Languages: eng Pagination: 87-92 Citation Subset: IM |
Affiliation:
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Department of Epidemiology, University of Colorado Denver, Aurora, 80045, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity
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physiology* Adolescent African Americans Child Diabetes, Gestational / epidemiology* European Continental Ancestry Group Female Hispanic Americans Humans Male Obesity / epidemiology*, physiopathology* Pregnancy Prenatal Exposure Delayed Effects / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR00069/RR/NCRR NIH HHS; R01 DK068001/DK/NIDDK NIH HHS; R01 DK068001-05/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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