Document Detail

Association of estrogen receptor beta gene polymorphism with bone mineral density.
MedLine Citation:
PMID:  10708589     Owner:  NLM     Status:  MEDLINE    
Chromosomal mapping of the human estrogen receptor beta (ERbeta) gene by fluorescence in situ hybridization (FISH) reveals that ERbeta is located at human chromosome 14, region q23-24.1, where the aberration of DNA copy number in the bone disorders is frequently involved. Then, we investigated the association between dinucleotide (cytosine-adenine; CA) repeat polymorphism located in the flanking region of ERbeta gene and bone mineral density (BMD) in 204 healthy postmenopausal Japanese women. The genotype was classified into "A" through "O" according to the number of the repeats, from 18 to 32. BMD was expressed in Z score (a deviation from the weight-adjusted average BMD of each age using the standard deviation as a unit). When we separate the subjects into two groups bearing at least one I allele (26 CA repeats) and those who did not, the former subjects had significantly higher Z score of L2-4 BMD (mean +/- standard deviation; 0.674 +/- 1.53 vs 0.128 +/- 1.38; P = 0.027). These data suggest that genetic variation at the ERbeta locus may be associated with some determinants for BMD and the possible involvements of this polymorphism in the cause of postmenopausal osteoporosis in Japanese women.
S Ogawa; T Hosoi; M Shiraki; H Orimo; M Emi; M Muramatsu; Y Ouchi; S Inoue
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  269     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-04-19     Completed Date:  2000-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  537-41     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
Department of Geriatric Medicine, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113, Japan.
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MeSH Terms
Base Sequence
Bone Density*
Chromosome Mapping
Chromosomes, Human, Pair 14
DNA Primers
Estrogen Receptor beta
In Situ Hybridization, Fluorescence
Microsatellite Repeats / genetics
Polymorphism, Genetic*
Receptors, Estrogen / genetics*
Reg. No./Substance:
0/DNA Primers; 0/Estrogen Receptor beta; 0/Receptors, Estrogen

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