Document Detail

Association of endothelial protein C receptor haplotypes, factor V Leiden and recurrent first trimester pregnancy loss.
MedLine Citation:
PMID:  18539144     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We evaluated whether the endothelial protein C receptor (EPCR) haplotypes A1 and A3 exert effects on the development of recurrent pregnancy loss (RPL) in association with factor V Leiden. DESIGN AND METHODS: We determined the EPCR haplotypes A1 and A3 and factor V Leiden in 49 women with a history of RPL and 48 parous controls. RESULTS: In carriers of factor V Leiden the A1 haplotype decreased the relative risk for RPL from 2.2 to 1.0. CONCLUSIONS: The EPCR A1 haplotype tends to modulate the risk for RPL in carriers of factor V Leiden.
Pierre Hopmeier; Helene Puehringer; Mick van Trotsenburg; Johanna Atamaniuk; Christian Oberkanins; Astrid Dossenbach-Glaninger
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Publication Detail:
Type:  Journal Article     Date:  2008-05-27
Journal Detail:
Title:  Clinical biochemistry     Volume:  41     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-21     Completed Date:  2008-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1022-4     Citation Subset:  IM    
Department of Laboratory Medicine, Rudolfstiftung Hospital, Vienna, Austria.
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MeSH Terms
Abortion, Habitual / genetics*
Antigens, CD / genetics*
DNA / genetics
Factor V / genetics*
Polymorphism, Genetic
Pregnancy Trimester, First
Receptors, Cell Surface / genetics*
Risk Factors
Reg. No./Substance:
0/Antigens, CD; 0/PROCR protein, human; 0/Receptors, Cell Surface; 0/factor V Leiden; 9001-24-5/Factor V; 9007-49-2/DNA

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