Document Detail


Association of endothelial protein C receptor haplotypes, factor V Leiden and recurrent first trimester pregnancy loss.
MedLine Citation:
PMID:  18539144     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: We evaluated whether the endothelial protein C receptor (EPCR) haplotypes A1 and A3 exert effects on the development of recurrent pregnancy loss (RPL) in association with factor V Leiden. DESIGN AND METHODS: We determined the EPCR haplotypes A1 and A3 and factor V Leiden in 49 women with a history of RPL and 48 parous controls. RESULTS: In carriers of factor V Leiden the A1 haplotype decreased the relative risk for RPL from 2.2 to 1.0. CONCLUSIONS: The EPCR A1 haplotype tends to modulate the risk for RPL in carriers of factor V Leiden.
Authors:
Pierre Hopmeier; Helene Puehringer; Mick van Trotsenburg; Johanna Atamaniuk; Christian Oberkanins; Astrid Dossenbach-Glaninger
Related Documents :
16962924 - Peripartum and perioperative management of the anticoagulated patient.
25296654 - Efficacy of dehydroepiandrosterone to overcome the effect of ovarian ageing (ditto): a ...
15006834 - Evaluation of the association between hereditary thrombophilias and recurrent pregnancy...
25332324 - Improving women's diet quality preconceptionally and during gestation: effects on birth...
2604004 - Role for central angiotensin ii in control of blood pressure during pregnancy.
17169694 - Normal sonographic values of maternal spleen size throughout pregnancy.
Publication Detail:
Type:  Journal Article     Date:  2008-05-27
Journal Detail:
Title:  Clinical biochemistry     Volume:  41     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-21     Completed Date:  2008-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1022-4     Citation Subset:  IM    
Affiliation:
Department of Laboratory Medicine, Rudolfstiftung Hospital, Vienna, Austria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / genetics*
Antigens, CD / genetics*
DNA / genetics
Factor V / genetics*
Female
Haplotypes*
Humans
Polymorphism, Genetic
Pregnancy
Pregnancy Trimester, First
Receptors, Cell Surface / genetics*
Risk Factors
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/PROCR protein, human; 0/Receptors, Cell Surface; 0/factor V Leiden; 9001-24-5/Factor V; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  XRASGRP2 expression during early development of Xenopus embryos.
Next Document:  Atrial natriuretic peptide stability.