| Association of endogenous insulin secretion and mode of therapy with body fat and serum leptin levels in diabetic subjects. | |
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MedLine Citation:
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PMID: 9826219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Insulin is one of the hormonal regulators of leptin synthesis and participates in adipose tissue maintenance. The present study was undertaken to clarify the association of endogenous insulin secretion and mode of therapy with body fat and serum leptin levels in diabetic subjects. We measured the fasting serum C-peptide level, as an estimate of endogenous insulin secretion, and the serum leptin level in 176 Japanese diabetic subjects (79 men and 97 women; age, 55.9+/-14.3 years; body mass index [BMI], 23.8+/-4.1 kg/m2 [mean+/-SD]). Thirty-one subjects were treated with diet therapy alone, 66 with sulfonylurea (SU), and 79 with insulin (including 29 with type I diabetes mellitus). Body fat was analyzed by the impedance method. Serum leptin levels significantly correlated with the BMI and body fat and were higher in women, mainly because of their greater body fat. Serum C-peptide concentrations positively correlated with body fat and serum leptin in subjects treated with diet and SU. In insulin-treated type II diabetic subjects, both serum C-peptide and the daily insulin dose were weakly associated with body fat and serum leptin. In those subjects, despite a lower percent body fat and body fat mass, serum leptin concentrations (10.3+/-8.4 ng/mL) were comparable to the levels in subjects treated with diet (8.8+/-8.5 ng/mL). When compared within the same BMI and body fat groups (BMI 20 to 25 and > 25 kg/m2) including the control subjects matched for age and sex, serum leptin levels were higher in insulin-treated type II diabetic subjects versus the control subjects and diabetic patients treated with diet or SU. Stepwise regression analysis for all of the diabetic subjects showed that both the serum C-peptide level and exogenous insulin administration, as well as the BMI, gender, and age, were determinants of the serum leptin level. In conclusion, endogenous insulin secretion is closely associated with body fat and serum leptin in diabetic subjects treated with diet therapy and SU. In Japanese insulin-treated type II diabetic subjects, both endogenous and exogenous insulin are associated with body fat and serum leptin, which is maintained at levels comparable to or somewhat higher than the levels in control subjects and diabetic patients treated without insulin. |
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Authors:
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S Nagasaka; S Ishikawa; T Nakamura; A Kawakami; K Rokkaku; H Hayashi; I Kusaka; M Higashiyama; T Saito |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 47 ISSN: 0026-0495 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1998-12-02 Completed Date: 1998-12-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1391-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, Jichi Medical School, Tochigi, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue* Adult Aged Body Mass Index* C-Peptide / blood Diabetes Mellitus, Type 1 / diet therapy, drug therapy, therapy* Female Humans Insulin / secretion* Ketones / blood Leptin Lipids / blood Male Middle Aged Proteins / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/C-Peptide; 0/Ketones; 0/Leptin; 0/Lipids; 0/Proteins; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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