Document Detail

Association of elevated plasma aldosterone-to-renin ratio with future cardiovascular events in patients with essential hypertension.
MedLine Citation:
PMID:  23107914     Owner:  NLM     Status:  Publisher    
BACKGROUND:: We investigated the relationship between the renin/aldosterone profiles of patients with essential hypertension and their prognosis using a long-term follow-up study design. METHODS:: The cohort consisted of 125 Japanese patients with essential hypertension whose plasma-renin activity (PRA) (ng/ml per h), plasma-aldosterone concentration (PAC) (ng/dl), and ratio of PAC to PRA [aldosterone-renin ratio (ARR)] were determined under hospitalization from 1984 to 1993. The patients were divided into two groups according to their ARRs relative to the 50th percentile of the ARR value (ARR = 5.5); the low-ARR group (ARR <5.5, n = 66) and high-ARR group (ARR > 5.5, n = 59). Their clinical outcomes were monitored during follow-up by the attending physicians. RESULTS:: Ninety-six patients with essential hypertension (77% of the original cohort) were eligible for the analyses. The mean follow-up time was 18.6 ± 5.2 years. The cardiovascular morbidity was significantly higher in the high-ARR group than in the low-ARR group 3.2 vs. 2.4 per 100 patient-years, respectively (P = 0.014 by Kaplan-Meier analysis). Among the cardiovascular events, the incidence of stroke was 2.7-fold higher in the high-ARR group than in the low-ARR group. High ARR was an independent risk marker for cardiovascular events by Cox proportional hazards model analysis. CONCLUSION:: High ARR was an independent risk marker for cardiovascular events in patients with essential hypertension.
Tomohiko Kisaka; Ryoji Ozono; Takafumi Ishida; Yukihito Higashi; Tetsuya Oshima; Yasuki Kihara
Related Documents :
16418784 - Effect of teriparatide [rhpth(1-34)] on bmd when given to postmenopausal women receivin...
24021944 - Gastrointestinal bleeding and subsequent risk of thromboembolic events during support w...
2509014 - The application of plasma tartrate-resistant acid phosphatase to assess changes in bone...
9102064 - The use of etidronate and calcium versus calcium alone in the treatment of postmenopaus...
11239174 - Treatment of unruptured cerebral aneurysms in california.
25060064 - Mechanical thrombectomy in acute occlusion of the carotid-t: a retrospective single cen...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-26
Journal Detail:
Title:  Journal of hypertension     Volume:  -     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
aDepartments of Cardiovascular Medicine bGeneral Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Interactive relations of blood pressure and age to subclinical cerebrovascular disease.
Next Document:  Intensive induction chemotherapy followed by early high-dose therapy and hematopoietic stem cell tra...