| Association of early-onset pre-eclampsia in first pregnancy with normotensive second pregnancy outcomes: a population-based study. | |
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MedLine Citation:
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PMID: 20497414 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate pregnancy outcomes in normotensive second pregnancy following pre-eclampsia in first pregnancy. DESIGN: Population-based retrospective cohort study. SETTING: State of Missouri in the USA. SAMPLE: White European origin or African-American women who delivered their first two non-anomalous singleton pregnancies between 20 and 44 weeks of gestation in Missouri, USA, 1989-2005, without chronic hypertension, renal disease or diabetes mellitus (n = 12 835). METHODS: Pre-eclampsia or delivery at 34 weeks of gestation or less in first pregnancy was defined as early-onset pre-eclampsia, whereas late-onset pre-eclampsia was defined as pre-eclampsia with delivery after 34 weeks of gestation. Multivariate regression models were fitted to estimate the crude and adjusted odds ratios and 95% confidence intervals. MAIN OUTCOME MEASURES: Preterm delivery, large and small-for-gestational-age infant, Apgar scores at 5 minutes, fetal death, caesarean section, placental abruption. RESULTS: Women with early-onset pre-eclampsia in first pregnancy were more likely to be younger, African-American, recipients of Medicaid, unmarried and smokers. Despite a second normotensive pregnancy, women with early-onset pre-eclampsia in their first pregnancy had greater odds of a small-for-gestational-age infant, preterm birth, fetal death, caesarean section and placental abruption in the second pregnancy, relative to women with late-onset pre-eclampsia, after controlling for confounders. Moreover, maternal ethnic origin modified the association between early-onset pre-eclampsia in the first pregnancy and preterm births in the second pregnancy. Having a history of early-onset pre-eclampsia reduces the odds of having a large-for-gestational-age infant in the second pregnancy. CONCLUSION: A history of early-onset pre-eclampsia is associated with increased odds of adverse pregnancy outcomes despite a normotensive second pregnancy. |
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Authors:
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J J Chang; L J Muglia; G A Macones |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-05-25 |
Journal Detail:
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Title: BJOG : an international journal of obstetrics and gynaecology Volume: 117 ISSN: 1471-0528 ISO Abbreviation: BJOG Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-11 Completed Date: 2010-09-21 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 100935741 Medline TA: BJOG Country: England |
Other Details:
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Languages: eng Pagination: 946-53 Citation Subset: AIM; IM |
Affiliation:
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Department of Community Health in Epidemiology, Saint Louis University School of Public Health, 3545 Lafayette Avenue, St. Louis, MO 63104, USA. changdalton@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abruptio Placentae
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etiology Adolescent Adult Cesarean Section / statistics & numerical data Female Fetal Death / etiology Gravidity Humans Infant, Newborn Infant, Small for Gestational Age Pre-Eclampsia* Pregnancy Pregnancy Outcome* Retrospective Studies Risk Factors Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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KL2 RR024994-02/RR/NCRR NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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