| Association of diabetes and cigarette smoke exposure on the glycemia and liver glycogen of pregnant Wistar rats. | |
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MedLine Citation:
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PMID: 19030744 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate cigarette smoke exposure and/or diabetes association effects on the glycemia and liver glycogen levels of pregnant Wistar rats. METHODS: 60 adult rats were randomly distributed into (n=10/group): non-diabetic exposed to filtered air (G1); non-diabetic exposed to cigarette smoke only before pregnancy (G2); non-diabetic exposed to cigarette smoke before and during pregnancy (G3); diabetic exposed to filtered air (G4); diabetic exposed to cigarette smoke only before pregnancy (G5), and diabetic exposed to cigarette smoke before and during pregnancy (G6). Glycemia was determined at days 0 and 21 of pregnancy. Liver samples were collected for liver glycogen determinations. RESULTS: At day 21 of pregnancy, glycemia was higher in G5 and G6 compared to G4 group. G2 (2.43+/-0.43), G3 (3.20+/-0.49), G4 (2.62+/-0.34), G5 (2.65+/-0.27) and G6 groups (1.94+/-0.35) presented decreased liver glycogen concentrations compared to G1 (4.20+/-0.18 mg/100mg liver tissue) (p<0.05). G5 and G6 groups presented decreased maternal weight gain and litter weight. CONCLUSIONS: Severe diabetes and cigarette smoke exposure, alone or associated, caused impairment in liver glycogen storage at term pregnancy. Due to the fact that liver glycogen storages were considered determinant for glucose tolerance, it is relevant to point out a rigid clinical glycemic control and to stop smoking so earlier in pregnancy programming. |
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Authors:
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Yuri Karen Sinzato; Paula Helena Ortiz Lima; Carlos Eduardo Meirelles dos Santos; Kleber Eduardode Campos; Marilza Vieira Cunha Rudge; Débora Cristina Damasceno |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta cirúrgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia Volume: 23 ISSN: 1678-2674 ISO Abbreviation: Acta Cir Bras Publication Date: 2008 Nov-Dec |
Date Detail:
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Created Date: 2008-11-25 Completed Date: 2009-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9103983 Medline TA: Acta Cir Bras Country: Brazil |
Other Details:
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Languages: eng Pagination: 481-5 Citation Subset: IM |
Affiliation:
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Laboratory of Experimental Research in Gynecology and Obstetrics, Botucatu Medical School, UNESP, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Blood Glucose / analysis* Diabetes Mellitus, Experimental / metabolism, physiopathology* Female Fetus / drug effects* Glucose Tolerance Test Liver Glycogen / analysis*, metabolism Maternal Exposure / adverse effects* Pregnancy Random Allocation Rats Rats, Wistar Tobacco Smoke Pollution / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Liver Glycogen; 0/Tobacco Smoke Pollution |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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