Document Detail

Association of depression with peripheral leukocyte counts in EPIC-Norfolk--role of sex and cigarette smoking.
MedLine Citation:
PMID:  12670606     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the associations among depression, smoking behaviour and enumerative measures of immunity in a population-based cohort study. METHODS: Participants in the European Prospective Investigation into Cancer and Nutrition in Norfolk, England, aged 40-80 years, were identified through age-sex general practice registers. After exclusions for prevalent conditions, white blood cell (WBC) counts and a measure of depressive episode history were available from 11,367 participants and, after a mean interval of 44 months, from 11,857 at a second health check. The measure of depression was completed between health checks. RESULTS: Observed associations between leukocyte counts and depression for men were weakened following adjustment for cigarette smoking. There was an incremental elevation in age-smoking adjusted mean WBC count by recency of depression such that there was a 3.1% (P=.03) and 5.6% (P=.0004) difference across depression history subgroups (never, lifetime, current) at the first and second health checks, respectively. No age-smoking adjusted associations were observed for women. CONCLUSION: Following adjustment for age and cigarette smoking, these data provide evidence for an association between major depressive disorder and leukocyte counts for men, but not for women.
Paul Surtees; Nicholas Wainwright; Nicholas Day; Robert Luben; Carol Brayne; Kay-Tee Khaw
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of psychosomatic research     Volume:  54     ISSN:  0022-3999     ISO Abbreviation:  J Psychosom Res     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-02     Completed Date:  2003-09-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376333     Medline TA:  J Psychosom Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  303-6     Citation Subset:  IM    
Strangeways Research Laboratory, Institute of Public Health, University of Cambridge, Worts Causeway, England, UK.
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MeSH Terms
Aged, 80 and over
Body Mass Index
Depressive Disorder, Major / blood*,  diagnosis,  epidemiology
Diagnostic and Statistical Manual of Mental Disorders
Leukocyte Count
Middle Aged
Prospective Studies
Sex Distribution
Smoking / blood*,  epidemiology

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