Document Detail

Association of deep vein thrombosis type with clinical phenotype of chronic thromboembolic pulmonary hypertension.
MedLine Citation:
PMID:  21930318     Owner:  NLM     Status:  Publisher    
BACKGROUND: Chronic thromboembolic pulmonary hypertension (CTEPH) has been considered to be caused by single or recurrent pulmonary embolism (PE) arising from deep vein thrombosis (DVT). In Japan, female predominance and association of HLA-B*5201 with CTEPH unrelated to DVT were reported. In acute PE residual proximal DVT is associated with larger obstruction of pulmonary arteries. However, it remains uncertain whether DVT and the type of DVT are associated with clinical phenotype of CTEPH. PURPOSE: To clarify the association of DVT and DVT type with clinical phenotype of CTEPH. METHODS: Among 98 consecutive patients who underwent 16 or 64-slice multidetector CT angiography and indirect venography, 91 patients (66% female, age: 56±3years) with adequate images were enrolled. The associations of DVT and DVT type with pulmonary hemodynamics, CT obstruction index and other clinical parameters were analyzed. RESULTS: DVT was found in 45 patients (49.5%) (distal: 12, proximal: 33), and was significantly associated with male gender and recurrent type. Furthermore, it was more frequent in HLA-B*5201-negative, and d-dimer positive patients. Compared with distal DVT, proximal DVT was associated with male gender, larger CT obstruction index (48.6±13.0 vs. 34.1±13.2%, p=0.004), and higher mean pulmonary arterial pressure (48.2±12.8 vs. 40.8±7.9mmHg, p=0.03). Proximal DVT was significantly associated with the central type of CTEPH only in HLA-B*5201-negative patients. CONCLUSIONS: The existence and type of DVT were associated with clinical phenotype of CTEPH, and proximal DVT might contribute to the central type of CTEPH in only HLA-B*5201-negative patients.
Masashi Kantake; Nobuhiro Tanabe; Toshihiko Sugiura; Ayako Shigeta; Noriyuki Yanagawa; Takayuki Jujo; Naoko Kawata; Hiroyuki Amano; Yukiko Matsuura; Rintaro Nishimura; Ayumi Sekine; Seiichiro Sakao; Yasunori Kasahara; Koichiro Tatsumi
Related Documents :
9397588 - Intramural coronary artery disease in swine with naturally occurring hypertrophic cardi...
1118668 - The pathogenesis of single experimental infections with strongylus vulgaris in foals.
2939818 - Immediate and long-term effects of angioplasty-balloon dilation on normal rabbit iliac ...
7206598 - Case report and study of collagen metabolism in marfan's syndrome.
19127318 - Spontaneous coronary artery dissection in the postpartum period.
19517058 - Parallel transverse-sigmoid sinus harboring dural arteriovenous malformation. how to di...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-17
Journal Detail:
Title:  International journal of cardiology     Volume:  -     ISSN:  1874-1754     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Thiazolidinediones can prevent new onset atrial fibrillation in patients with non-insulin dependent ...
Next Document:  Technical note: Development and testing of a radio transmission pH measurement system for continuous...