| Association of cytochrome P450 1B1 polymorphism with first-trimester miscarriage. | |
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MedLine Citation:
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PMID: 16978616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether the cytochrome P450 1B1 (CYP1B1) Val432Leu polymorphism is associated with risk of miscarriage. We also analyzed the possible interaction between this polymorphism and caffeine intake. DESIGN: The population-based case-control study included 507 women with miscarriage in the first trimester of pregnancy and 908 controls with a normal first-trimester pregnancy. The controls were frequency matched to cases. The material was analyzed taking maternal age, smoking habits, alcohol intake, caffeine intake, fetal karyotype, nausea, and vomiting into consideration. SETTING: University hospital and primary care facility. MAIN OUTCOME MEASURE(S): CYP1B1 Val432Leu genotype frequencies in cases and controls. RESULT(S): Carriers of the CYP1B1 432 Val/Val genotype were at a higher risk of miscarriage in the first trimester of pregnancy (odds ratio = 1.46; 95% confidence interval, 1.02-2.08). We also found a significant interaction between genotype and caffeine intake. CONCLUSION(S): CYP1B1 Val432Leu polymorphism is associated with first-trimester miscarriage, and it may also modify the risk among coffee drinkers. |
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Authors:
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Anna-Helena Karypidis; Torbjörn Söderström; Anna Nordmark; Fredrik Granath; Sven Cnattingius; Anders Rane |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-09-14 |
Journal Detail:
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Title: Fertility and sterility Volume: 86 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-30 Completed Date: 2006-12-01 Revised Date: 2012-01-24 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1498-503 Citation Subset: IM |
Affiliation:
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Department of Medical Laboratory Sciences and Technology, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital (Huddinge), Stockholm, Sweden. helena.karypidis@ki.se |
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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epidemiology*,
genetics* Aryl Hydrocarbon Hydroxylases Cytochrome P-450 Enzyme System / genetics* Female Genetic Markers / genetics Genetic Predisposition to Disease / epidemiology, genetics Genetic Testing / methods* Humans Polymorphism, Single Nucleotide / genetics* Pregnancy Pregnancy Trimester, First / genetics* Prevalence Risk Assessment / methods* Risk Factors Sweden / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Genetic Markers; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.14.14.1/Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1/cytochrome P450, family 1, subfamily B, polypeptide 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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