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Association of coronary plaque composition and arterial remodelling: A optical coherence tomography study.
MedLine Citation:
PMID:  22341594     Owner:  NLM     Status:  Publisher    
BACKGROUND: Conflicting data have been reported about the association between plaque composition and remodelling index (RI). The aim of this study is to evaluate the relationship between plaque morphology obtained by optical coherence tomography (OCT) and arterial remodelling. METHODS AND RESULTS: OCT and intravascular ultrasound imaging pull back was performed at corresponding sites on 94 lesions in 47 patients. OCT plaque characteristics for lipid content, fibrous cap thickness, thin-cap fibroatheroma (TCFA), plaque rupture, thrombus, calcification and erosion were derived using validated criteria. Compared with intermediate/negative remodelling (RI<1.0), positive remodelling (RI>1.0) was associated with presence of higher lipid pool (2.86±0.42 vs. 2.20±0.78; p<0.001), thin fibrous cap (47.86±25.43μm vs. 74.41±32.41μm; p<0.001), TCFA>3mm (82.1% vs. 22.7%; p<0.0001), plaque rupture and thrombus (42.8% vs. 19.7%; p=0.024), and higher plaque burden (73.70 vs. 70.70; p=0.048). No difference was observed in the presence of calcification and plaque erosions. CONCLUSIONS: Coronary lesions with positive remodelling show higher incidences of vulnerable plaque and plaque rupture across the lesion length. This potentially explains the correlation between unstable coronary syndromes and positive remodelling.
Sudhir Rathore; Mitsuyasu Terashima; Hitoshi Matsuo; Yoshihisa Kinoshita; Masashi Kimura; Etsuo Tsuchikane; Kenya Nasu; Mariko Ehara; Yasushi Asakura; Osamu Katoh; Takahiko Suzuki
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-20
Journal Detail:
Title:  Atherosclerosis     Volume:  -     ISSN:  1879-1484     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2012-2-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Department of Cardiology, St George's Hospital, Blackshaw Road, Tooting, London, UK; Department of Cardiology, Toyohashi Heart Center, 21-1, Gobudori, Oyama-cho, Toyohashi 441-8530, Japan.
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