Document Detail

Association of coronary disease with segment-specific intimal-medial thickening of the extracranial carotid artery.
MedLine Citation:
PMID:  7648658     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Several investigators have evaluated relations between risk factors and intimal-medial thickness (IMT) of the extracranial carotid arteries and between IMT and clinical cardiovascular disease. Different indexes of IMT have been used as referents. We compared the strength of association of various IMT measurements with coronary artery disease as measured at coronary angiography. METHODS AND RESULTS: We quantified the mean of the IMT for 12 sites of the extracranial carotid arteries (common carotid, bifurcation, internal carotid, near and far walls, and left and right sides [mean aggregate]) as well as for various combinations of sites (eg, segment-specific means, far walls only, maximum of any site) in 270 patients with or free of coronary artery disease. Models including age and all the indexes of IMT identified the mean aggregate as the only variable independently associated with the status of coronary atherosclerosis for the group as a whole. Next most strongly correlated was the mean common plus bifurcation. When classification algorithms were tested for ability to correctly classify case patients and control subjects, the mean bifurcation, mean common plus bifurcation, and mean aggregate were most strongly related to case-control status; however, the predictive power of the mean common was also strong. CONCLUSIONS: These data support use of the mean aggregate extracranial carotid IMT for correlation with the status of coronary atherosclerosis; however, the data also support use of the mean common plus bifurcation, since there is little increase in predictive power of the mean aggregate over this index. Use of the common carotid alone is also justifiable and may be preferable for certain analyses.
J R Crouse; T E Craven; A P Hagaman; M G Bond
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  92     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-09-25     Completed Date:  1995-09-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1141-7     Citation Subset:  AIM; IM    
Department of Medicine, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, NC, USA.
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MeSH Terms
Age Factors
Carotid Artery Diseases / complications,  epidemiology,  ultrasonography*
Carotid Artery, Common / ultrasonography
Carotid Artery, Internal / ultrasonography
Case-Control Studies
Coronary Artery Disease / complications*,  epidemiology,  ultrasonography
Logistic Models
Middle Aged
Predictive Value of Tests
Risk Factors
Sex Factors
Tunica Intima / ultrasonography
Tunica Media / ultrasonography
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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