Document Detail


Association of coronary aortic calcium with abdominal aortic calcium detected on lateral dual energy x-ray absorptiometry spine images.
MedLine Citation:
PMID:  19616658     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The association of abdominal aortic calcium (AAC) on lateral spine bone densitometry with coronary artery calcium (CAC) has not been reported. We studied 33 men and 73 women who had CAC scored with electron beam computed tomography at the eighth visit of the Rancho Bernardo study and lateral spine dual-energy x-ray absorptiometry images fully evaluable for AAC at the ninth study visit. The association between CAC level and AAC tertile was assessed by ordinal logistic regression analysis. The odds ratio of having a greater CAC score for those with an AAC score in the top tertile (24-point scale score > or =5) was 6.42 (95% confidence interval 2.28 to 18.1) and using the 8-point scale (score > or =3) was 3.38 (95% confidence interval 1.26 to 9.07) compared with those with AAC scores in the bottom tertiles, adjusted for age, gender, systolic blood pressure, total and high-density lipoprotein cholesterol, smoking status, and diabetes. A 24-point AAC score of > or =5 had a sensitivity of 65% and specificity of 70% to detect a high CAC score (> or =400 points). An 8-point AAC score of > or =3 had a sensitivity of 45% and specificity of 78%. In conclusion, a high level of AAC on lateral spine dual-energy x-ray absorptiometry was strongly associated with coronary artery disease and might be commonly encountered because bone densitometry is indicated for all women aged > or =65 years and all men aged > or =70 years. Its presence should be reported to the patient's physician to identify and manage modifiable risk factors.
Authors:
John T Schousboe; Diane Claflin; Elizabeth Barrett-Connor
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2009-06-06
Journal Detail:
Title:  The American journal of cardiology     Volume:  104     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-20     Completed Date:  2009-08-31     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  299-304     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Aged
Aortic Diseases / radiography*
Calcinosis / radiography*
Coronary Artery Disease / radiography*
Female
Humans
Male
Middle Aged
Risk Factors
Sensitivity and Specificity
Spine / radiography*
Tomography, X-Ray Computed
Grant Support
ID/Acronym/Agency:
AG028507/AG/NIA NIH HHS; AG07181/AG/NIA NIH HHS; DK31801/DK/NIDDK NIH HHS; R01 AG028507/AG/NIA NIH HHS; R01 AG028507-02/AG/NIA NIH HHS; R01 DK031801/DK/NIDDK NIH HHS; R01 DK031801-16/DK/NIDDK NIH HHS; R37 AG007181/AG/NIA NIH HHS; R37 AG007181-21/AG/NIA NIH HHS
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