Document Detail

Association of concomitant fibromyalgia with worse disease activity score in 28 joints, health assessment questionnaire, and short form 36 scores in patients with rheumatoid arthritis.
MedLine Citation:
PMID:  19479706     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the association of the presence of fibromyalgia (FM) with the Disease Activity Score in 28 joints (DAS28), the Health Assessment Questionnaire (HAQ), and the Medical Outcomes Study Short Form 36 (SF-36) health survey in patients with rheumatoid arthritis (RA). METHODS: A total of 270 outpatients with RA were enrolled in a prospective cross-sectional study. The patients underwent clinical evaluation and application of the HAQ and SF-36 questionnaires. Disease activity was evaluated using the DAS28 score. FM and RA diagnoses were made according to American College of Rheumatology criteria. RESULTS: The overall prevalence of FM was 13.4%. This group of patients had a higher prevalence of female sex, older mean age, higher functional class, and longer morning stiffness than patients with only RA. Mean +/- SD DAS28 scores were significantly higher in patients with RA and FM (5.36 +/- 0.99) than in patients with RA only (4.03 +/- 1.39; P < 0.001). In a multivariable linear regression analysis, FM was an important predictor of the DAS28 score, even after adjusting for the erythrocyte sedimentation rate, number of swollen joints, functional class, number of disease-modifying antirheumatic drugs currently in use, current dose of steroids, and articular erosions. HAQ and SF-36 scores were also worse in patients with RA and associated FM. CONCLUSION: FM is related to worse scores on the DAS28, HAQ, and SF-36 in patients with RA. The presence of FM may have major implications in the interpretation of the DAS28 score because it is related to higher scores independently of objective evidence of RA activity.
Aline Ranzolin; João Carlos Tavares Brenol; Markus Bredemeier; Jairo Guarienti; Marcele Rizzatti; Daniel Feldman; Ricardo Machado Xavier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  61     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-16     Completed Date:  2009-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  794-800     Citation Subset:  AIM; IM    
Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
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MeSH Terms
Arthritis, Rheumatoid / epidemiology*,  pathology,  physiopathology
Brazil / epidemiology
Cross-Sectional Studies
Fatigue / epidemiology,  physiopathology
Fibromyalgia / diagnosis,  epidemiology*,  physiopathology
Health Status
Joints / pathology,  physiopathology*
Middle Aged
Pain / epidemiology,  pathology,  physiopathology
Pain Threshold
Prospective Studies
Severity of Illness Index
Comment In:
Arthritis Rheum. 2009 Jun 15;61(6):715-6   [PMID:  19479689 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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