| Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure. | |
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MedLine Citation:
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PMID: 19219041 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the association of common variants at the NPPA-NPPB locus with circulating concentrations of the natriuretic peptides, which have blood pressure-lowering properties. We genotyped SNPs at the NPPA-NPPB locus in 14,743 individuals of European ancestry, and identified associations of plasma atrial natriuretic peptide with rs5068 (P = 8 x 10(-70)), rs198358 (P = 8 x 10(-30)) and rs632793 (P = 2 x 10(-10)), and of plasma B-type natriuretic peptide with rs5068 (P = 3 x 10(-12)), rs198358 (P = 1 x 10(-25)) and rs632793 (P = 2 x 10(-68)). In 29,717 individuals, the alleles of rs5068 and rs198358 that showed association with increased circulating natriuretic peptide concentrations were also found to be associated with lower systolic (P = 2 x 10(-6) and 6 x 10(-5), respectively) and diastolic blood pressure (P = 1 x 10(-6) and 5 x 10(-5)), as well as reduced odds of hypertension (OR = 0.85, 95% CI = 0.79-0.92, P = 4 x 10(-5); OR = 0.90, 95% CI = 0.85-0.95, P = 2 x 10(-4), respectively). Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension. |
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Authors:
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Christopher Newton-Cheh; Martin G Larson; Ramachandran S Vasan; Daniel Levy; Kenneth D Bloch; Aarti Surti; Candace Guiducci; Sekar Kathiresan; Emelia J Benjamin; Joachim Struck; Nils G Morgenthaler; Andreas Bergmann; Stefan Blankenberg; Frank Kee; Peter Nilsson; Xiaoyan Yin; Leena Peltonen; Erkki Vartiainen; Veikko Salomaa; Joel N Hirschhorn; Olle Melander; Thomas J Wang |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-02-15 |
Journal Detail:
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Title: Nature genetics Volume: 41 ISSN: 1546-1718 ISO Abbreviation: Nat. Genet. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-02-25 Completed Date: 2009-04-02 Revised Date: 2011-05-17 |
Medline Journal Info:
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Nlm Unique ID: 9216904 Medline TA: Nat Genet Country: United States |
Other Details:
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Languages: eng Pagination: 348-53 Citation Subset: IM |
Affiliation:
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Center for Human Genetic Research, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA. cnewtoncheh@chgr.mgh.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Atrial Natriuretic Factor / genetics* Blood Pressure / genetics* Case-Control Studies Female Gene Frequency Genetic Predisposition to Disease Humans Hypertension / blood, genetics Linkage Disequilibrium Male Middle Aged Natriuretic Peptide, Brain / genetics* Natriuretic Peptides / blood* Polymorphism, Single Nucleotide* |
| Grant Support | |
ID/Acronym/Agency:
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089061//Wellcome Trust; G0601463: 80983//Medical Research Council; HL66582/HL/NHLBI NIH HHS; K23 HL074077-05/HL/NHLBI NIH HHS; K23 HL080025-04/HL/NHLBI NIH HHS; K23-HL-074077/HL/NHLBI NIH HHS; K23-HL-080025/HL/NHLBI NIH HHS; K24-HL-04334/HL/NHLBI NIH HHS; N01-HC-25195/HC/NHLBI NIH HHS; R01 HL093328/HL/NHLBI NIH HHS; R01-DK-081572/DK/NIDDK NIH HHS; R01-HL-070896/HL/NHLBI NIH HHS; R01-HL-083197/HL/NHLBI NIH HHS; R01-HL-086875/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/NPPA protein, human; 0/Natriuretic Peptides; 114471-18-0/Natriuretic Peptide, Brain; 85637-73-6/Atrial Natriuretic Factor |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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