Document Detail


Association of a common polymorphism in the factor XIII gene with myocardial infarction.
MedLine Citation:
PMID:  9459313     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Factor XIII when activated by thrombin, crosslinks fibrin, however its role in thrombotic disorders is unknown. A common point mutation (G-->T) in exon 2 of the A-subunit gene which codes for an amino acid change three amino acids from the thrombin activation site (Factor XIIIVal34Leu) is a candidate for a role in the pathogenesis of acute myocardial infarction. Factor XIII genotype frequencies were determined in a case-control study of 398 caucasian patients and 196 healthy controls. Patients had undergone angiography for investigation of coronary artery disease and were evaluated for a history of myocardial infarction. The prevalence of the mutation was lower in patients with myocardial infarction than without (32% vs. 50%), p = 0.0009 and than in controls (32% vs. 48%), p = 0.005. Patients possessing the mutation with a history of myocardial infarction had higher PAI-1 concentrations (mean, 27.9 vs. 16.7 ng/ml, p = 0.004) and the PAI-1 4G/4G genotype was commoner (43% vs. 26%, p = 0.03). There was no difference in PAI-1 4G/4G genotype (33% vs. 32%) and PAI-1 levels (mean, 21.0 vs. 20.9 ng/ml) in patients possessing wild type with MI compared to those without MI. These results indicate that the G-->T mutation coding for factor XIIIVal34Leu is protective against myocardial infarction and suggest a mechanism whereby elevated levels of PAI-1 may contribute to vascular risk.
Authors:
H P Kohler; M H Stickland; N Ossei-Gerning; A Carter; H Mikkola; P J Grant
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  79     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-03-12     Completed Date:  1998-03-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  8-13     Citation Subset:  IM    
Affiliation:
Unit of Molecular Vascular Medicine, Leeds General Infirmary, UK.
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Factor XIII / genetics*
Female
Fibrinogen / metabolism
Humans
Leucine
Male
Middle Aged
Myocardial Infarction / genetics*,  metabolism
Odds Ratio
Plasminogen Activator Inhibitor 1 / metabolism
Point Mutation*
Polymorphism, Genetic*
Risk Factors
Valine
Chemical
Reg. No./Substance:
0/Plasminogen Activator Inhibitor 1; 61-90-5/Leucine; 7004-03-7/Valine; 9001-32-5/Fibrinogen; 9013-56-3/Factor XIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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