Document Detail


Association of common carotid intima-media thickness and lipoprotein(a) with coronary artery disease.
MedLine Citation:
PMID:  15751520     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Carotid artery intimal medial thickness is a simple, non-invasive and reproducible clinical tool to evaluate atherosclerosis and predict coronary artery disease. Lipoprotein(a) levels are related to both atherogenesis and thrombogenesis and may be a key link between lipid and coronary artery disease. This study evaluated the association of carotid intimal medial thickness and lipoprotein(a) with coronary artery disease. METHODS AND RESULTS: We studied 185 randomly selected patients hospitalized for coronary angiogram in our institute. There were 110 angiographically proven patients of coronary artery disease with mean age of 55.8 +/- 9 years (range 34-72 years) and 75 subjects with normal coronary artery anatomy with mean age of 54.8 +/- 8 years (range 34-68 years). The mean carotid intimal medial thickness of subjects with coronary artery disease was significantly higher than in subjects without coronary artery disease (0.84 +/- 0.16 mm v. 0.65 +/- 0.15 mm, p<0.001). The mean carotid intimal medial thicknesses in patients with triple vessel, double vessel and single vessel disease were 0.96 +/- 0.12 mm, 0.84 +/- 0.11 mm and 0.78 +/- 0.13 mm, respectively (p=0.05). The mean lipoprotein(a) of subjects with coronary artery disease was significantly higher than in subjects without coronary artery disease (35.9 +/- 22.3 mg/dl v. 19.1 +/- 21.2 mg/dl, p<0.001). Mean lipoprotein(a) levels in subjects with carotid intimal medial thickness <0.80 was 26.4 +/- 24.2 mg/dl and in subjects with carotid intimal medial thickness > or = 0.80 was 32.1 +/- 22.1 mg/dl (p=0.05). CONCLUSIONS: There is a strong correlation between carotid and coronary atherosclerosis and carotid intimal medial thickness is a good predictor of presence and extent of coronary artery disease. Lipoprotein(a) level is a powerful independent risk factor for atherosclerosis. Carotid intimal medial thickness and lipoprotein(a) in conjoint can predict coronary artery disease reliably.
Authors:
Satyendra Tewari; Nitish Garg; Aditya Kapoor; Alkesh Jain; Uttam Singh; M M Godbole; Nakul Sinha
Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Indian heart journal     Volume:  56     ISSN:  0019-4832     ISO Abbreviation:  Indian Heart J     Publication Date:    2004 Nov-Dec
Date Detail:
Created Date:  2005-03-08     Completed Date:  2005-03-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0374675     Medline TA:  Indian Heart J     Country:  India    
Other Details:
Languages:  eng     Pagination:  642-5     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow. stewari@sgpgi.ac.in
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers / blood
Carotid Arteries / radiography*
Cholesterol / blood
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Coronary Angiography / methods
Coronary Artery Disease / blood,  diagnosis*,  epidemiology,  etiology,  radiography
Cross-Sectional Studies
Female
Humans
India / epidemiology
Lipoprotein(a) / blood*
Male
Middle Aged
Predictive Value of Tests
Risk Factors
Severity of Illness Index
Triglycerides / blood
Tunica Intima / radiography
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipoprotein(a); 0/Triglycerides; 57-88-5/Cholesterol

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