| Association of clinical manifestations with HLA-B alleles in Takayasu arteritis. | |
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MedLine Citation:
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PMID: 9951811 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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HLA-DNA typing using PCR-SSOP and PCR-DCP methods was performed in 85 patients with Takayasu arteritis and 492 healthy controls who had been typed for HLA by serological method. Frequencies of HLA-B52 (B*5201) and B39 (B*3901 and B*3902) were significantly increased in the patients. Frequency of HLA-DRB1*1502 was also increased but it was suggested to be a reflection of its linkage disequilibrium with B52. Association of HLA-B52 and B39 with seven clinical manifestations--pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance--in 132 HLA-typed patients with Takayasu arteritis was studied. In HLA-B52 positive TA patients, aortic regurgitation (vs B52(-)-B39(+), OR=3.8, P<0.05, vs B52(-)-B39(-), OR=5.49, P<0.001), ischemic heart disease (vs B52(-)-B39(+), OR=12.05, P<0.05, vs B52(-)-B39(-), OR=2.85, P<0.05), and pulmonary infarction (vs B52(-)-B39(+), OR=5.74, P<0.03) were found to be significantly prevalent. On the other hand, in HLA-B39 positive TA patients, frequency of renal artery stenosis was significantly increased (vs B52(+)-B39(-), OR=12.14, P<0.001, vs B52(-)-B39(-), OR=5.21, P<0.03). These observations have suggested that HLA-B52 molecule and B39 molecule would contribute to different clinical manifestations by binding different antigenic peptides to cause inflammations. Thus HLA-B molecule may play an important role in pathogenesis or determining clinical manifestations of Takayasu arteritis. |
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Authors:
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H Kitamura; Y Kobayashi; A Kimura; F Numano |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: International journal of cardiology Volume: 66 Suppl 1 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 1998 Oct |
Date Detail:
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Created Date: 1999-04-13 Completed Date: 1999-04-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: IRELAND |
Other Details:
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Languages: eng Pagination: S121-6 Citation Subset: IM |
Affiliation:
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Third Department of Internal Medicine, School of Medicine, Tokyo Medical and Dental University, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles DNA / analysis DNA Primers / chemistry Female Gene Frequency HLA-B Antigens / genetics* HLA-DR Antigens / genetics Histocompatibility Testing Humans Male Polymerase Chain Reaction Takayasu Arteritis / diagnosis, genetics* |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/HLA-B Antigens; 0/HLA-B39; 0/HLA-B52; 0/HLA-DR Antigens; 128338-86-3/HLA-DRB1 antigen; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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