Document Detail

Association of clear cell carcinoma of the endometrium with a high rate of venous thromboembolism.
MedLine Citation:
PMID:  19370896     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To document the rate of clinically significant venous thromboembolism (VTE) in patients with clear cell carcinoma of the endometrium (CCC-E). STUDY DESIGN: Institutional review board permission was obtained to identify all cases of CCC-E between 1994 and 2004. Controls with high grade endometrial cancers were matched for stage, age and date of diagnosis. RESULTS: Complete data were available for 29. Age ranged from 38 to 85 (mean, 64.6) years. Thirty-five percent of the patients had stage I tumors, 10% stage II, 27.5% stage III and 27.5% stage IV tumors. Fifty-eight matched controls were selected. Overall there were 18 VTE events: 10 (34.5%) in patients with CCC-E and 8 (13.8%) in the controls (OR = 3.68, p = 0.032). More VTE occurred in patients with stage III/IV disease (n = 16) than those with early stage (n = 2). VTE in patients with CCC-E occurred at presentation or with disease recurrence rather than in the postoperative period (8 vs. 1). Among patients with CCC-E, VTE had an adverse effect on survival, with a hazard ratio of 3.65 (95% CI, 3.14-4.16; p = 0.011). CONCLUSION: Patients with CCC-E have greater risk of VTE than patients with other high-risk endometrial cancers. Consideration should be given to extended prophylaxis in patients with CCC-E to prevent VTE.
Lisa Lee; Leslie Garrett; Hang Lee; Esther Oliva; Neil Horowitz; Linda R Duska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  54     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-04-17     Completed Date:  2009-05-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  133-8     Citation Subset:  IM    
Division of Gynecologic Oncology, Biostatistics Center, Massachusetts General Hospital, Boston, USA.
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MeSH Terms
Adenocarcinoma, Clear Cell / epidemiology*,  mortality,  pathology
Aged, 80 and over
Case-Control Studies
Confounding Factors (Epidemiology)
Endometrial Neoplasms / epidemiology*,  mortality,  pathology
Fibrinolytic Agents / therapeutic use*
Middle Aged
Neoplasm Staging
Primary Prevention
Venous Thromboembolism / epidemiology*,  mortality,  pathology
Reg. No./Substance:
0/Fibrinolytic Agents

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