Document Detail

Association of circulating transforming growth factor beta, tumor necrosis factor alpha and basic fibroblast growth factor with restenosis after transluminal angioplasty.
MedLine Citation:
PMID:  17475518     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To assess prospectively the early time course of Transforming Growth Factor beta-1 (TGFbeta-1), basic Fibroblast Growth Factor (bFGF) and Tumor Necrosis Factor alpha (TNFalpha) as possible contributors to restenosis development after angioplasty. DESIGN: Prospective Study. METHODS: The levels of the soluble forms of these factors in the early response to Percutaneous Transluminal Angioplasty (PTA) in the arteries of the lower limb were prospectively assessed. 32 patients with peripheral arterial occlusive disease (PAOD), presenting with intermittent claudication (Fontaine stage IIb) were scheduled for angioplasty treatment. Serum levels of TGFbeta-1, TNFalpha and bFGF were assessed before intervention, 15 and 60 minutes after, 24 hours after as well as 2 and 4 weeks after intervention. We compared the distribution patterns between patients treated with balloon angioplasty and patients who required secondary stent implantation. Endpoint was the development of restenosis within 6 months after interventional treatment, defined as a lumen diameter reduction of more than 50% by ultrasound measurement compared to the result after PTA. RESULTS: The patients who later developed restenosis had significantly higher levels of TGFbeta-1 at 15 minutes, 24 hours and 2 weeks after PTA (p<0.05). TNFalpha and bFGF were only detected in a few patients and no significant change of serum levels was observed. CONCLUSION: The results demonstrate a possible role of TGFbeta-1 in the formation of restenosis after PTA.
M Wildgruber; W Weiss; H Berger; O Wolf; H-H Eckstein; P Heider
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Publication Detail:
Type:  Journal Article     Date:  2007-05-02
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  34     ISSN:  1078-5884     ISO Abbreviation:  Eur J Vasc Endovasc Surg     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-11     Completed Date:  2007-08-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  35-43     Citation Subset:  IM    
Department of Vascular Surgery, Klinikum rechts der Isar, Technical University of Munich, Germany.
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MeSH Terms
Angioplasty, Balloon / adverse effects*
Biological Markers / blood
Enzyme-Linked Immunosorbent Assay
Fibroblast Growth Factor 2 / blood*
Follow-Up Studies
Graft Occlusion, Vascular / blood*,  radiography
Intermittent Claudication / radiography,  therapy*
Middle Aged
Prospective Studies
Risk Factors
Severity of Illness Index
Transforming Growth Factor beta / blood*
Tumor Necrosis Factor-alpha / blood*
Reg. No./Substance:
0/Biological Markers; 0/Transforming Growth Factor beta; 0/Tumor Necrosis Factor-alpha; 103107-01-3/Fibroblast Growth Factor 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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