Document Detail

Association of circulating matrix metalloproteinase-1, but not adiponectin, with advanced coronary artery disease.
MedLine Citation:
PMID:  18823886     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Recent evidence suggests that high tissue matrix metalloproteinase-1 (MMP-1) and low adiponectin may serve as biomarkers of atherosclerosis. Results on the associations of circulating MMP-1 and adiponectin concentrations are scarce. We hypothesized that patients with multivessel coronary artery disease (CAD) have elevated high-sensitivity C-reactive protein (hs-CRP), MMP-1 but low adiponectin levels, and concomitant measurements of these biomarkers could improve predictive strength for advanced CAD.
RESEARCH DESIGN AND METHODS: We analyzed concentrations of MMP-1, hs-CRP and adiponectin in 217 subjects with angiographically documented multivessel CAD (two-, or three-vessel disease by luminal stenosis >or=50%) and 81 controls. MMP-1 and hs-CRP were notably higher in patients with CAD; while adiponectin was not significantly different between two groups. Levels of hs-CRP positively correlated with body mass index and left ventricular dysfunction (R(2)=0.16, P<0.0001); while adiponectin was significantly associated with age, gender, and levels of cholesterol and triglyceride (R(2)=0.09, P<0.0001). On the contrary, MMP-1 was not associated with any clinical cardiovascular risk factors, and still an independent predictor (OR=1.49, P<0.0001) of multivessel CAD after the adjustment of clinical risk factors and hs-CRP.
CONCLUSION: Elevated MMP-1 and hs-CRP, but not low adiponectin concentrations, could predict the presence of advanced coronary atherosclerosis. In addition, MMP-1 may serve as a more specific marker for significant CAD independent of hs-CRP.
Juey-Jen Hwang; Wei-Shiung Yang; Fu-Tien Chiang; Ming-Fong Chen; Hung-Ju Lin; Por-Jau Huang; Sandy Huey-Jen Hsu; Sung-Kuei Lai; Yen-Wen Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-28
Journal Detail:
Title:  Atherosclerosis     Volume:  204     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-04     Completed Date:  2009-08-05     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  293-7     Citation Subset:  IM    
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
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MeSH Terms
Adiponectin / blood
Biological Markers / blood
C-Reactive Protein / analysis
Case-Control Studies
Coronary Angiography
Coronary Artery Disease / blood,  enzymology*,  radiography
Disease Progression
Linear Models
Logistic Models
Matrix Metalloproteinase 1 / blood*
Middle Aged
Predictive Value of Tests
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin; 0/Biological Markers; 9007-41-4/C-Reactive Protein; EC Metalloproteinase 1

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