Document Detail

Association of childhood perennial allergic rhinitis with subclinical airflow limitation.
MedLine Citation:
PMID:  19968650     Owner:  NLM     Status:  In-Process    
BACKGROUND: Allergic rhinitis (AR) is a relevant risk factor for the onset of asthma, and a close association exists between the nose and the bronchi. Recently, it has been evidenced that the duration of AR and mite allergy represent high risks for spirometric impairment in allergic adults. AIM: To evaluate a group of AR children, without bronchial symptoms, to investigate spirometric impairments. METHODS: Two hundred children with moderate-severe AR were consecutively evaluated. Clinical examination, skin prick test, and spirometry were performed in all children. RESULTS: Thirty-one percent of the children had forced expiratory flow at 25% and 75% of the pulmonary volume (FEF25-75%)<80% of the predicted values and 11% had both forced expiratory volume in 1 s and FEF25-75%<80% of the predicted values. Rhinitis duration and sensitization to house dust mites were significantly associated with impaired values of these spirometric parameters. CONCLUSION: This study highlights the close link between the upper and the lower airways and the role of some risk factors, such as long duration and mite sensitization, as early prognostic markers of bronchial involvement in children with AR and perceiving nasal symptoms alone.
G Ciprandi; M Capasso
Publication Detail:
Type:  Journal Article     Date:  2009-11-23
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  40     ISSN:  1365-2222     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  398-402     Citation Subset:  IM    
Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, University of Genoa, Genoa, Italy.
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Comment In:
Clin Exp Allergy. 2010 Jun;40(6):951; author reply 951-2   [PMID:  20557551 ]

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