Document Detail

Association of cerebrospinal fluid deficiency of 5-methyltetrahydrofolate, but not S-adenosylmethionine, with reduced concentrations of the acid metabolites of 5-hydroxytryptamine and dopamine.
MedLine Citation:
PMID:  7520379     Owner:  NLM     Status:  MEDLINE    
1. Folate deficiency, or inborn errors of folate metabolism, cause reduced turnover of 5-hydroxytryptamine (serotonin), and perhaps dopamine, in the central nervous system. The mechanism by which this occurs are not known. One possibility is that this is mediated by deficiency of the methyl-donor S-adenosylmethionine. 2. To test this in humans, we have measured cerebrospinal fluid concentrations of 5-hydroxyindoleacetic acid and homovanillic acid, metabolites of 5-hydroxytryptamine and dopamine, respectively, in children with inborn errors of the methyl-transfer pathway. These children are naturally deficient in 5-methyltetrahydrofolate, S-adenosylmethionine or both before treatment, and replete with S-adenosylmethionine, but not necessarily with 5-methyltetrahydrofolate, during treatment. 3. Children with subnormal cerebrospinal fluid concentrations of 5-methyltetrahydrofolate had significantly reduced concentrations of 5-hydroxyindoleacetic acid and homovanillic acid. Children with subnormal cerebrospinal fluid concentrations of S-adenosylmethionine did not have significantly reduced concentrations of these metabolites. 4. We conclude that the mechanism by which deficiency of 5-methyltetrahydrofolate causes reduced 5-hydroxytryptamine and dopamine turnover is unlikely to be mediated by S-adenosylmethionine.
R Surtees; S Heales; A Bowron
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  86     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-09-22     Completed Date:  1994-09-22     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  697-702     Citation Subset:  IM    
Medical Unit, Institute of Child Health, London, U.K.
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MeSH Terms
Child, Preschool
Dopamine / metabolism
Homovanillic Acid / cerebrospinal fluid*
Hydroxyindoleacetic Acid / cerebrospinal fluid*
Metabolism, Inborn Errors / cerebrospinal fluid*
S-Adenosylmethionine / cerebrospinal fluid*
Serotonin / metabolism
Tetrahydrofolates / cerebrospinal fluid*,  deficiency
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Tetrahydrofolates; 134-35-0/5-methyltetrahydrofolate; 29908-03-0/S-Adenosylmethionine; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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