Document Detail


Association of breast-fed neonatal hyperbilirubinemia with UGT1A1 polymorphisms: 211G>A (G71R) mutation becomes a risk factor under inadequate feeding.
MedLine Citation:
PMID:  23014115     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Breastfeeding jaundice is a well-known phenomenon, but its pathogenesis is still unclear. Increased production of bilirubin, impaired hepatic uptake and metabolism of bilirubin, and increased enterohepatic circulation of bilirubin account for most cases of pathological neonatal hyperbilirubinemia. We previously reported that 211G>A (G71R) mutation of the UGT1A1 gene is prevalent in East Asians and is associated with the development of neonatal hyperbilirubinemia. Recently, significant association of G71R mutation with hyperbilirubinemia in breast-fed neonates was reported. We enrolled 401 full-term Japanese infants, who were exclusively breast-fed without supplementation of formula before developing hyperbilirubinemia, and classified them into two groups based on the degree of maximal body weight loss during the neonatal period. We analyzed the sex, gestational age, delivery mode, body weight at birth, maximal body weight loss and genotypes of G71R and (TA)(7) polymorphic mutations of UGT1A1. Statistical analysis revealed that maximal body weight loss during the neonatal period is the only independent risk factor for the development of neonatal hyperbilirubinemia. The effect of G71R mutation on neonatal hyperbilirubinemia is significant in neonates with 5% or greater maximal body weight loss and its influence increases in parallel with the degree of maximal body weight loss. Our study indicates that G71R mutation is a risk factor for neonatal hyperbilirubinemia only in infants with inadequate breastfeeding and suggests that adequate breastfeeding may overcome the genetic predisposing factor, G71R mutation, for the development of neonatal hyperbilirubinemia.
Authors:
Hiroko Sato; Toshihiko Uchida; Kentaro Toyota; Miyako Kanno; Taeko Hashimoto; Masashi Watanabe; Tomohiro Nakamura; Gen Tamiya; Kuraaki Aoki; Kiyoshi Hayasaka
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Publication Detail:
Type:  Historical Article; Journal Article     Date:  2012-09-27
Journal Detail:
Title:  Journal of human genetics     Volume:  58     ISSN:  1435-232X     ISO Abbreviation:  J. Hum. Genet.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-25     Completed Date:  2013-11-14     Revised Date:  2014-03-28    
Medline Journal Info:
Nlm Unique ID:  9808008     Medline TA:  J Hum Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  7-10     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Breast Feeding / adverse effects*
Female
Genetic Predisposition to Disease*
Glucuronosyltransferase / genetics*
History, 16th Century
Humans
Hyperbilirubinemia, Neonatal / epidemiology,  genetics*
Incidence
Infant, Newborn
Japan / epidemiology
Male
Mutation
Polymorphism, Genetic / genetics*
Risk Factors
Chemical
Reg. No./Substance:
EC 2.4.1.-/UGT1A1 enzyme; EC 2.4.1.17/Glucuronosyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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