Document Detail

Association between brachial-ankle pulse wave velocity and endothelium-dependent and -independent coronary vasomotor function.
MedLine Citation:
PMID:  21039754     Owner:  NLM     Status:  In-Process    
1. Coronary endothelial function and brachial-ankle pulse wave velocity (baPWV) are independent predictors of cardiovascular events. Thus, in the present study we examined the relationship between baPWV and endothelium-dependent and -independent coronary vasodilatory functions. 2. Sixty-five patients (12 diabetic and 53 non-diabetic) with no significant stenosis of the coronary artery were studied and baPWV determined. After cardiac catheterization, graded doses of bradykinin (BK; 0.2, 0.6 and 2.0 μg/min), nitroglycerin (NTG; 250 μg) and papaverine (Pa; 12 mg) were administered into the left anterior descending coronary artery. Coronary blood flow (CBF) was measured using a Doppler flow wire. 3. In the 65 patients, an inverse correlation was found between baPWV and the percentage change in epicardial coronary artery diameter (Δ%CoD), as well as the percentage change in CBF (Δ%CBF), following administration of BK (endothelium-dependent vasodilator). Moreover, inverse correlations were found between baPWV and Δ%CoD following administration of NTG (endothelium-independent vasodilator) and Δ%CBF following administration of Pa (endothelium-independent vasodilator). 4. Multivariate analysis revealed diabetes to be independently and significantly associated with baPWV, BK-induced Δ%CBF and Δ%CoD and Pa-induced Δ%CBF. 5. In conclusion, the results of the present study suggest that increased baPWV is associated with endothelium-dependent and -independent coronary vasodilatory dysfunction. Non-invasive and straightforward baPWV measurement may be useful for the assessment of coronary risk factors, particularly in diabetic patients.
Tomohide Yoshino; Ichiro Nakae; Tetsuya Matsumoto; Kenichi Mitsunami; Minoru Horie
Related Documents :
22748194 - The diagnostic utility of cardiac biomarkers in dialysis patients.
8487824 - Evidence of impaired endothelium-dependent coronary vasodilatation in patients with ang...
1516154 - Epicardial coronary artery responses to acetylcholine are impaired in hypertensive pati...
8430424 - Cadmium-induced attenuation of coronary blood flow in the perfused rat heart.
282784 - Creatine kinase isoenzymes in the confirmation of acute myocardial infarction.
3609034 - Gold 195m in the assessment of the cold pressor test by first pass radionuclide ventric...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  38     ISSN:  1440-1681     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  34-41     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Clinical and Experimental Pharmacology and Physiology © 2010 Blackwell Publishing Asia Pty Ltd.
Departments of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Seta, Otsu, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloprot...
Next Document:  Voluntary exercise does not affect stress-induced tachycardia, but improves resistance to cardiac ar...