Document Detail

Association of bovine neonatal Fc receptor alpha-chain gene (FCGRT) haplotypes with serum IgG concentration in newborn calves.
MedLine Citation:
PMID:  12514749     Owner:  NLM     Status:  MEDLINE    
This report describes allelic variation in FCGRT (which encodes the alpha-chain of FcRn) and its association with variation of IgG concentration in neonatal calves. Five SNPs were identified by sequencing 1305 bp of FCGRT genomic DNA from a multi-breed panel of 96 cattle and 27 founders of a reference population. These SNPs defined five FCGRT haplotypes that were verified by segregation and used to test association of FCGRT with neonatal IgG concentration in a case-control study. This study established that dams with FCGRT haplotype 3 had a significantly greater risk of failure of passive transfer in their calves (odds ratio [OR] = 3.80, CI95% 1.10-13.18, p = 0.035). Calves with FCGRT haplotype 2 were less likely to have high levels of passively acquired immunoglobulin (OR = 0.18, CI95% 0.05-0.68, p = 0.011). These results indicate that the bovine FCGRT haplotype markers are in linkage disequilibrium with genetic risk factors affecting passive transfer of IgG in beef cattle, an important determinant of neonatal calf morbidity and mortality.
William W Laegreid; Michael P Heaton; James E Keen; William M Grosse; Carol G Chitko-McKown; Timothy P L Smith; John W Keele; Gary L Bennett; Thomas E Besser
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Mammalian genome : official journal of the International Mammalian Genome Society     Volume:  13     ISSN:  0938-8990     ISO Abbreviation:  Mamm. Genome     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-01-06     Completed Date:  2003-06-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100916     Medline TA:  Mamm Genome     Country:  United States    
Other Details:
Languages:  eng     Pagination:  704-10     Citation Subset:  IM    
United States Department of Agriculture, Agricultural Research Service, U.S. Meat Animal Research Center (MARC), P.O. Box 166, State Spur 18D, Clay Center, Nebraska 68933, USA.
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MeSH Terms
Animals, Newborn / immunology*
Antigens, CD / genetics*
Chromosome Mapping
Chromosome Segregation
Histocompatibility Antigens Class I
Immunity, Maternally-Acquired
Immunoglobulin G / blood*
Linkage Disequilibrium
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Receptors, Fc / genetics*
Risk Factors
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Reg. No./Substance:
0/Antigens, CD; 0/Fc receptor, neonatal; 0/Fc(alpha) receptor; 0/Histocompatibility Antigens Class I; 0/Immunoglobulin G; 0/Receptors, Fc

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