Document Detail


Association of body mass index and risk of death from pancreas cancer in Asians: findings from the Asia Cohort Consortium.
MedLine Citation:
PMID:  23044748     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We aimed to examine the association between BMI and the risk of death from pancreas cancer in a pooled analysis of data from the Asia Cohort Consortium. The data for this pooled analysis included 883 529 men and women from 16 cohort studies in Asian countries. Cox proportional-hazards models were used to estimate the hazard ratios and 95% confidence intervals for pancreas cancer mortality in relation to BMI. Seven predefined BMI categories (<18.5, 18.5-19.9, 20.0-22.4, 22.5-24.9, 25.0-27.4, 27.5-29.9, ≥30) were used in the analysis, with BMI of 22.5-24.9 serving as the reference group. The multivariable analyses were adjusted for known risk factors, including age, smoking, and a history of diabetes. We found no statistically significant overall association between each BMI category and the risk of death from pancreas cancer in all Asians, and obesity was unrelated to the risk of mortality in both East Asians and South Asians. Age, smoking, and a history of diabetes did not modify the association between BMI and the risk of death from pancreas cancer. In planned subgroup analyses among East Asians, an increased risk of death from pancreas cancer among those with a BMI less than 18.5 was observed for individuals with a history of diabetes; hazard ratio=2.01 (95% confidence interval: 1.01-4.00) (P for interaction=0.07). The data do not support an association between BMI and the risk of death from pancreas cancer in these Asian populations.
Authors:
Yingsong Lin; Rong Fu; Eric Grant; Yu Chen; Jung Eun Lee; Prakash C Gupta; Kunnambath Ramadas; Manami Inoue; Shoichiro Tsugane; Yu-Tang Gao; Akiko Tamakoshi; Xiao-Ou Shu; Kotaro Ozasa; Ichiro Tsuji; Masako Kakizaki; Hideo Tanaka; Chien-Jen Chen; Keun-Young Yoo; Yoon-Ok Ahn; Habibul Ahsan; Mangesh S Pednekar; Catherine Sauvaget; Shizuka Sasazuki; Gong Yang; Yong-Bing Xiang; Waka Ohishi; Takashi Watanabe; Yoshikazu Nishino; Takeshi Suzuki; San-Lin You; Sue K Park; Dong-Hyun Kim; Faruque Parvez; Betsy Rolland; Dale McLerran; Rashmi Sinha; Paolo Boffetta; Wei Zheng; Mark Thornquist; Ziding Feng; Daehee Kang; John D Potter
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-5
Journal Detail:
Title:  European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)     Volume:  -     ISSN:  1473-5709     ISO Abbreviation:  Eur. J. Cancer Prev.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9300837     Medline TA:  Eur J Cancer Prev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
aDepartment of Public Health, Aichi Medical University School of Medicine, Nagakute Departments of bEpidemiology cClinical Studies, Radiation Effects Research Foundation, Hiroshima dEpidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo eDepartment of Public Health, Hokkaido University Graduate School of Medicine, Sapporo fDivision of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine gDivision of Cancer Epidemiology and Prevention, Miyagi Cancer Center Research Institute, Miyagi hDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan iDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington jDepartment of Environmental Medicine, New York University School of Medicine kDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University lThe Tisch Cancer Institute and Institute for Translational Epidemiology, Mount Sinai School of Medicine, New York mDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland nDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee Departments of oHealth Studies pMedicine qHuman Genetics rComprehensive Cancer Center, The University of Chicago, Chicago, Illinois, USA sDepartment of Food and Nutrition, Sookmyung Women's University tDepartment of Preventive Medicine, Seoul National University College of Medicine uCancer Research Institute, Seoul National University vDepartment of Biomedical Science, Seoul National University Graduate School, Seoul wDepartment of Social and Preventive Medicine, Hallym University College of Medicine, Chuncheon, Korea xHealis-Sekhsaria Institute for Public Health, Navi Mumbai yDivision of Radiation Oncology, Regional Cancer Center, Medical College Campus, Trivandrum, India zDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, China IGenomics Research Center, Academia Sinica IIGraduate Institute of Epidemiology, College of Public Health, National Taiwan University IIISchool of Public Health, National Defense Medical Center, Taipei, Taiwan IVScreening Group, International Agency for Research on Cancer International Prevention Research Institute, Lyon, France VCentre for Public Health Research, Massey University, Wellington, New Zealand.
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