| Association of body fat distribution and family histories of breast and ovarian cancer with risk of postmenopausal breast cancer. | |
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MedLine Citation:
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PMID: 8237968 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors recently published data from a prospective cohort study of postmenopausal women (N Engl J Med 1992;326:1323-9) which suggested that a high waist/hip ratio was associated with a significantly increased risk of breast cancer in women with a positive family history of breast cancer. Since families with aggregations of breast and ovarian cancer demonstrate more consistent genetic linkage to markers on chromosome 17q than do families with breast cancer alone, the authors performed additional analyses to examine whether the previously observed associations with waist/hip ratio differed when family history of breast cancer was partitioned according to whether or not ovarian cancer was also present in a close relative. Between 1986 and 1990, 620 incident cases of breast cancer were identified in a cohort of 37,105 postmenopausal Iowa women. A family history of breast cancer in first-degree relatives was associated with a relative risk of 1.34 (95% confidence interval (CI) 1.07-1.69); a family history of both breast cancer and ovarian cancer was associated with a relative risk of 2.36 (95% CI 1.12-4.98). Consistent with the authors' findings after 4 years of follow-up, a high waist/hip ratio (> or = 80th percentile vs. < 80th percentile) was associated with increased risk of breast cancer in the presence of a family history of breast cancer (relative risk (RR) = 2.10, 95% CI 1.43-3.09) but not in the absence of a family history of breast cancer (RR = 1.12). The combination of a high waist/hip ratio with a family history of breast and ovarian cancer was associated with 4.83-fold increased risk (95% CI 1.55-15.1). Neither a family history of breast cancer nor a family history of ovarian cancer was associated with significantly increased risk in the absence of a high waist/hip ratio. |
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Authors:
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T A Sellers; S M Gapstur; J D Potter; L H Kushi; R M Bostick; A R Folsom |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of epidemiology Volume: 138 ISSN: 0002-9262 ISO Abbreviation: Am. J. Epidemiol. Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1993-12-22 Completed Date: 1993-12-22 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7910653 Medline TA: Am J Epidemiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 799-803 Citation Subset: IM |
Affiliation:
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Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454-1015. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue Aged Body Constitution* Breast Neoplasms / epidemiology*, genetics* Female Humans Linkage (Genetics) Middle Aged Ovarian Neoplasms / genetics* Postmenopause* Prospective Studies Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01-CA 39742/CA/NCI NIH HHS; T32 CA099607/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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