| Association of body composition and lung function in children with cystic fibrosis. | |
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MedLine Citation:
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PMID: 15668934 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Survival in cystic fibrosis has improved significantly in the last 30 years, with major therapeutic goals of delaying the progressive loss of pulmonary function and maintaining normal growth. Dual-energy X-ray absorptiometry (DEXA) was performed in children with cystic fibrosis (CF) to assess both bone mineral density and body composition. We hypothesised that there would be an association between body composition and pulmonary function in children with CF. Fifty subjects with CF (28 males), mean age 12.7 years, participated in the study. Body composition was determined by DEXA. Body mass index (BMI) was calculated from the ratio of weight/height2 (kg/m2). Lung function was assessed by spirometry. Most patients (78%) had mild lung disease. The mean forced expired volume in 1 sec percent predicted (FEV1% predicted) for the 50 patients was 79.2% (range, 24-117%). There was a strong association between FEV1% predicted and BMI (R=0.59, P=0.0001). Fat-free mass had positive association with pulmonary function tests (R=0.30, P=0.03). Although fat mass showed a positive correlation with pulmonary function, this association did not reach statistical significance. In our group of children with CF and mild lung disease, pulmonary function was more strongly associated with BMI than with fat and fat-free mass. |
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Authors:
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C C Pedreira; R G D Robert; V Dalton; M R Oliver; J B Carlin; P Robinson; F J Cameron |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Pediatric pulmonology Volume: 39 ISSN: 8755-6863 ISO Abbreviation: Pediatr. Pulmonol. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-01-31 Completed Date: 2005-06-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8510590 Medline TA: Pediatr Pulmonol Country: United States |
Other Details:
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Languages: eng Pagination: 276-80 Citation Subset: IM |
Affiliation:
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Department of Endocrinology and Diabetes, Royal Children's Hospital, Parkville, Victoria, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adipose Tissue / metabolism Adolescent Body Composition* Body Mass Index Bone Density Child Cystic Fibrosis / diagnosis, metabolism*, physiopathology* Energy Intake Female Humans Lung / physiopathology* Male Respiratory Function Tests |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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