Document Detail

Association of blood pressure and antihypertensive drugs with diurnal alpha-amylase activity.
MedLine Citation:
PMID:  21515315     Owner:  NLM     Status:  Publisher    
Salivary α-amylase (sAA) has been proposed as a marker of autonomic activity, but its association with blood pressure and antihypertensive drugs (AD) is unknown. Basal sAA rhythm was assessed immediately after awakening, 30min after awakening, 11am, 3pm, and 8pm in 78 older adults. Profiles differed significantly between men and women, with men lacking the typical decrease of sAA in the morning and showing more pronounced alterations throughout the day. A higher total output of sAA was found in individuals not using AD or being hypertensive, and especially pronounced in hypertensive individuals not using AD. These data indicates a difference between normotensives and hypertensives and an association of AD with characteristics of diurnal amylase. Findings highlight the usefulness of sAA as an index of autonomic imbalance in disease, and indicate sAA as a promising candidate to non-invasively study therapeutic treatment effects.
Jana Strahler; Clemens Kirschbaum; Nicolas Rohleder
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-21
Journal Detail:
Title:  International journal of psychophysiology : official journal of the International Organization of Psychophysiology     Volume:  -     ISSN:  1872-7697     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406214     Medline TA:  Int J Psychophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Department of Psychology, Technische Universität Dresden, 01062 Dresden, Germany; Department of Psychology, Philipps-Universität Marburg, 35032 Marburg, Germany.
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