| Association of blood lead levels with mortality in patients on maintenance hemodialysis. | |
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MedLine Citation:
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PMID: 21435426 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: The association between blood lead levels and mortality in patients on maintenance hemodialysis remains unclear. METHODS: A cross-sectional and 18-month prospective study included 927 patients on maintenance hemodialysis. Baseline variables and blood lead levels were measured before hemodialysis and categorized as 3 equal groups: high (>12.64 μg/dL), middle (8.51-12.64 μg/dL), and low (<8.51 μg/dL). Mortality and cause of death were recoded for longitudinal analyses. RESULTS: At baseline, after related variables were adjusted, logarithmic transformation of blood lead level was negatively related to log ferritin and positively related to the vintage of hemodialysis and the percentage of urban area patients. By the end of the follow-up, 59 patients had died. Kaplan-Meier survival analysis showed that the high blood lead level group had greater mortality than the low blood lead level group (log-rank test, P<.001). After adjustment for potential variables, Cox multivariate analysis demonstrated that by using the low blood lead level as the reference, high blood lead levels were associated with increased hazard ratios (HRs) for all-cause (HR 4.70; 95% confidence interval [CI], 1.92-11.49; P=.003), cardiovascular-cause (HR 9.71; 95% CI, 2.11-23.26; P=.005), and infection-cause (HR 5.35; 95% CI, 1.38-20.83; P=.046) 18-month mortality in patients on maintenance hemodialysis. Moreover, there was a significant trend (P=.032) of HRs for all-cause mortality among the 3 study groups. CONCLUSION: High blood lead level is associated with increased HRs for all-cause, cardiovascular-cause, and infection-cause 18-month mortality in patients on maintenance hemodialysis. |
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Authors:
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Ja-Liang Lin; Dan-Tzu Lin-Tan; Ching-Wei Hsu; Tzung-Hai Yen; Kuan-Hsing Chen; Hsiang-Hao Hsu; Tai-Chin Ho; Kuang-Hong Hsu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of medicine Volume: 124 ISSN: 1555-7162 ISO Abbreviation: Am. J. Med. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: United States |
Other Details:
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Languages: eng Pagination: 350-8 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Nephrology and Division of Clinical Toxicology, Chang Gung Memorial Hospital, Taipei, Lin-Kou Medical Center, Taoyuan, Chang Gung University and School of Medicine, Taoyuan, Taiwan, ROC. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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