| Association between vitamin D and pressure ulcers in older ambulatory adults: results of a matched case-control study. | |
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MedLine Citation:
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PMID: 21966215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Pressure ulcers are common among older adults, but knowledge about nutritional risk factors is still developing. Vitamin D deficiency is common in the elderly population and is required for normal skin proliferation. The role of vitamin D in pressure ulceration and wound healing is not known. The purpose of this case-control study was to determine the association between vitamin D levels and pressure ulceration in an older community-dwelling cohort. METHODS: All cases and controls were community-dwelling elderly older than 60 years in a primary care panel in Olmsted County, MN. Pressure ulcer cases were defined clinically. The controls were age-matched and gender-matched to controls without pressure ulceration. The main exposure variable was 25-hydroxyvitamin D levels in both groups. The other exposure variable was the Charlson Comorbidity Index used to measure medical comorbidity. The analysis included univariate and conditional logistic regression for 25-hydroxyvitamin D levels. RESULTS: The average (standard deviation) age of the study participants with a pressure ulcer was 80.46 years (±8.67), and the average vitamin D level was 30.92 ng/mL (±12.46). In univariate analysis, Vitamin D deficiency (levels < 25 ng/mL) was associated with pressure ulcers (odds ratio: 1.871, P = 0.0154). Comorbidities of the subjects calculated using the Charlson Comorbidity Index were also associated with pressure ulcers (odds ratio: 1.136, P < 0.001). In the final conditional logistical regression model, the association of Vitamin D and pressure ulcers became nonsignificant after adjustment for comorbid illness. CONCLUSION: Medical comorbidities increased the risk of pressure ulceration. Vitamin D deficiency was not an independent risk factor for pressure ulceration, and may be a marker of comorbid illness. |
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Authors:
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Usha R Kalava; Stephen S Cha; Paul Y Takahashi |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-08-02 |
Journal Detail:
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Title: Clinical interventions in aging Volume: 6 ISSN: 1178-1998 ISO Abbreviation: Clin Interv Aging Publication Date: 2011 |
Date Detail:
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Created Date: 2011-10-03 Completed Date: 2012-01-11 Revised Date: 2012-04-27 |
Medline Journal Info:
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Nlm Unique ID: 101273480 Medline TA: Clin Interv Aging Country: New Zealand |
Other Details:
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Languages: eng Pagination: 213-9 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Division of Primary Care Internal Medicine, Mayo Clinic, Rochester, MN, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Distribution Aged Aged, 80 and over Aging / physiology* Case-Control Studies Comorbidity Female Humans Male Middle Aged Minnesota / epidemiology Pilot Projects Pressure Ulcer / blood, epidemiology*, physiopathology Risk Factors Vitamin D / analogs & derivatives*, blood Vitamin D Deficiency / blood, epidemiology*, physiopathology Wound Healing / physiology* |
| Chemical | |
Reg. No./Substance:
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1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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