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Association between type 2 diabetes and rs10811661 polymorphism upstream of CDKN2A/B: a meta-analysis.
MedLine Citation:
PMID:  22623142     Owner:  NLM     Status:  Publisher    
To assess the association between type 2 diabetes and rs10811661 polymorphism, upstream of CDKN2A/B, a literature-based search was conducted to collect data. The pooled OR (odds ratio) and 95 % confidence intervals (CI) were used to assess the strength of association between rs10811661 polymorphism and type 2 diabetes. OR with 95 % CI were performed for allele contrasts, additive genetic model, dominant genetic model and recessive genetic model, respectively. The effect model was used if there was heterogeneity between studies. Funnel plots were used to predict publication bias. 17 studies with 29,990 cases and 40,977 controls were enrolled in this meta-analysis. Significant association was found in all of the four genetic models: allele contrast (OR = 1.21, 95 % CI 1.18-1.24), additive genetic model (OR = 1.51, 95 % CI 1.40-1.63), dominant genetic model (OR = 1.37, 95 % CI 1.28-1.47) and recessive genetic model (OR = 1.25, 95 % CI 1.21-1.29). The meta-analysis indicated that rs10811661 polymorphism was significantly associated with the risk of type 2 diabetes.
Hui Li; Xiaojun Tang; Qin Liu; Yang Wang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-24
Journal Detail:
Title:  Acta diabetologica     Volume:  -     ISSN:  1432-5233     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200299     Medline TA:  Acta Diabetol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
School of Public Health and Management, Chongqing Medical University, Chongqing, China.
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