| Association between thyroid microsomal antibodies of subclass IgG-1 and hypothyroidism in autoimmune postpartum thyroiditis. | |
| | |
MedLine Citation:
|
PMID: 3754185 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The potential role of thyroid microsomal (Mic) antibodies in the development of postpartum hypothyroidism was investigated in 34 euthyroid women, whose sera were found to contain Mic antibodies in pregnancy. Additional serum samples were obtained 2. 5 and 10-12 months after delivery and analysed for IgG class and IgG subclass levels of Mic antibodies by ELISA techniques. Characteristically, Mic antibodies decreased from early pregnancy to 2 months postpartum, increased two-fold 5 months postpartum and had returned 10-12 months postpartum to the early pregnancy level. Mic antibodies were predominantly subclass IgG-1 or IgG-4 with only minor contributions from IgG-2 and IgG-3. In each individual the percentage contribution made by each IgG subclass to Mic antibody was essentially similar in early pregnancy and the postpartum period despite changes in total IgG class Mic antibody. During the year following delivery, thyrotoxicosis alone (Graves' disease) developed in 5 women. In the remaining 29 patients the absolute levels of Mic antibodies of IgG-4 subclass were similar 5 months postpartum in women with maximal serum thyrotropin (TSH) greater than 20 mU/1 (mean optical density in ELISA +/- s.d.; 0.84 +/- 0.538; n = 13) and in women with maximal TSH less than 10 mU/l (0.69 +/- 0.457; n = 16). In contrast, significantly higher values were observed for Mic antibody of IgG-1 subclass in patients with TSH greater than 20 mU/l (1.14 +/- 0.440) compared with women with maximal TSH less than 10 mU/l (0.65 +/- 0.289) (P less than 0.001 by t-test for groups). These results imply that the magnitude of Mic antibody levels of subclass IgG-1 but not IgG-4 is associated with the development of postpartum hypothyroidism and possibly with tissue destruction in autoimmune thyroid disease in general. |
| | |
Authors:
|
R Jansson; P M Thompson; F Clark; S M McLachlan |
Related Documents
:
|
17851865 - Consequences of inadvertent radioiodine treatment of graves' disease and thyroid cancer... 8427205 - Effects of iodine deficiency on thyroid hormone metabolism and the brain in fetal rats:... 12481755 - Acog practice bulletin. thyroid disease in pregnancy. number 37, august 2002. american ... 474175 - Dissimulation function in some functional psychoses. 17187835 - Goats may experience reproductive failures and shed coxiella burnetii at two successive... 10839645 - Treatment of depression during pregnancy. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Clinical and experimental immunology Volume: 63 ISSN: 0009-9104 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 1986 Jan |
Date Detail:
|
Created Date: 1986-04-25 Completed Date: 1986-04-25 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 80-6 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Autoantibodies / analysis* Autoimmune Diseases / immunology* Female Graves Disease / immunology Humans Hypothyroidism / immunology* Immunoglobulin G / analysis* Microsomes / immunology Pregnancy Prospective Studies Puerperal Disorders / immunology* Thyroid Gland / immunology* |
| Chemical | |
Reg. No./Substance:
|
0/Autoantibodies; 0/Immunoglobulin G |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cytogenetic analysis in 100 spontaneous abortions in North-East Scotland.
Next Document: Antibodies to wheat germ agglutinin in coeliac disease.