Document Detail

Association between sympathetic activity and the atherogenic serum cholesterol fraction.
MedLine Citation:
PMID:  2182939     Owner:  NLM     Status:  MEDLINE    
A possible modulating influence of noradrenergic activity on serum lipoproteins was assessed under placebo conditions and following 4 weeks of sympathetic neurone blockade with debrisoquine in 9 normal subjects, 11 patients with mild essential hypertension, 9 normotensive, and 9 hypertensive hemodialysis patients. Plasma norepinephrine (NE) did not differ significantly among groups on placebo and was consistently reduced (P less than 0.05-0.001) by sympathetic blockade. The latter also decreased (P less than 0.05-0.001) plasma total cholesterol (C) as well as low and very low density lipoprotein cholesterol (LDL + VLDL-C) in the three patient groups. In the two dialysis groups, basal levels of plasma triglycerides (Tg) were increased and high density lipoprotein cholesterol (HDL-C) was diminished (P less than 0.01-0.001); sympathetic blockade lowered Tg and raised HDL-C (P less than 0.01-0.001). In normal subjects, sympathetic blockade did not significantly modify plasma lipoproteins. In the three patient groups, significant correlations (r = 0.62 - 0.88; P less than 0.05 - less than 0.001) existed between (a) basal plasma NE and total C or LDL + VLDL-C and (b) debrisoquine-induced changes in NE and changes in total LDL + VLDL-C. These findings suggest that in essential hypertension as well as in hemodialysis patients, the atherogenic C fraction, represented by LDL + VLDL-C, may be modulated by the noradrenergic activity.
P Weidmann; D C Schohn; W Riesen; H A Jahn; P Ferrari; S G Shaw; C Beretta-Piccoli
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Klinische Wochenschrift     Volume:  68     ISSN:  0023-2173     ISO Abbreviation:  Klin. Wochenschr.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-05-18     Completed Date:  1990-05-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985205R     Medline TA:  Klin Wochenschr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  269-76     Citation Subset:  IM    
Medizinisch Poliklinik, Universität Bern, Switzerland.
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MeSH Terms
Arteriosclerosis / physiopathology*
Blood Pressure / physiology
Cholesterol / blood*
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Cholesterol, VLDL / blood
Clinical Trials as Topic
Debrisoquin / therapeutic use
Heart Rate / physiology
Hypertension / drug therapy,  physiopathology*
Hypertension, Renal / physiopathology
Kidney Failure, Chronic / physiopathology
Middle Aged
Norepinephrine / physiology*
Renal Dialysis
Single-Blind Method
Sympathetic Nervous System / physiopathology*
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Cholesterol, VLDL; 1131-64-2/Debrisoquin; 51-41-2/Norepinephrine; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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